SL 0101-1

Modify Date: 2024-01-02 11:30:44

SL 0101-1 Structure
SL 0101-1 structure
Common Name SL 0101-1
CAS Number 77307-50-7 Molecular Weight 516.451
Density 1.6±0.1 g/cm3 Boiling Point 753.0±60.0 °C at 760 mmHg
Molecular Formula C25H24O12 Melting Point 128-132ºC
MSDS N/A Flash Point 255.6±26.4 °C

 Use of SL 0101-1


SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].

 Names

Name Kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside)
Synonym More Synonyms

 SL 0101-1 Biological Activity

Description SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].
Related Catalog
Target

IC50: 89 nM (RSK)[1].

References

[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 753.0±60.0 °C at 760 mmHg
Melting Point 128-132ºC
Molecular Formula C25H24O12
Molecular Weight 516.451
Flash Point 255.6±26.4 °C
Exact Mass 516.126770
PSA 182.19000
LogP 2.75
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.666
Storage condition -20℃

 Synthetic Route

 Synonyms

4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
3',4'-Di-O-acetylafzelin
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 3,4-di-O-acetyl-6-deoxy-α-L-mannopyranoside
3",4"-Diacetylafezelin
SL 0101-1
SL0101
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Price: ¥1900/1 mg

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