Afzelin

Modify Date: 2024-01-03 22:51:39

Afzelin Structure
Afzelin structure
Common Name Afzelin
CAS Number 482-39-3 Molecular Weight 432.378
Density 1.7±0.1 g/cm3 Boiling Point 765.6±60.0 °C at 760 mmHg
Molecular Formula C21H20O10 Melting Point N/A
MSDS Chinese USA Flash Point 272.4±26.4 °C

 Use of Afzelin


Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1].

 Names

Name afzelin
Synonym More Synonyms

 Afzelin Biological Activity

Description Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1].
Related Catalog
References

[1]. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 765.6±60.0 °C at 760 mmHg
Molecular Formula C21H20O10
Molecular Weight 432.378
Flash Point 272.4±26.4 °C
Exact Mass 432.105652
PSA 170.05000
LogP 2.37
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.748

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Synthetic Route

 Articles2

More Articles
Antibacterial effects of afzelin isolated from Cornus macrophylla on Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals.

Molecules 19(3) , 3173-80, (2014)

The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivi...

Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage.

PLoS ONE 8(4) , e61971, (2013)

Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human keratinocytes, resulting in skin inflammation, photoaging, and photocarcinogenesis. Adequate protec...

 Synonyms

kaempferol 3-O-α-L-rhamnopyranoside
kaempferol-3-rhamnoside
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-α-L-mannopyranoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
Kaempferol-3-O-α-L-rhamnoside
Kaempferol 3-O-Alpha-L-Rhamnoside
Afzelin
Trihydroxy-SL0101
4H-1-Benzopyran-4-one, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
Kaempferol 3-rhamnoside
3-O-α-rhamnosylkaempferol
Kaempferin
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