Disodium dihydrogen diphosphate

Modify Date: 2024-01-02 16:38:30

Disodium dihydrogen diphosphate structure	Common Name	Disodium dihydrogen diphosphate
	CAS Number	7758-16-9	Molecular Weight	221.93900
	Density	2.311 g/cm3 (25ºC)	Boiling Point	N/A
	Molecular Formula	H₂Na₂O₇P₂	Melting Point	988ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Disodium dihydrogen diphosphate

Disodium pyrophosphate (SAPP), a food additive, is an inorganic compound. Disodium pyrophosphate has potential hematotoxic and immunotoxic effects[1].

Name	Disodium pytophosphate
Synonym	More Synonyms

Description	Disodium pyrophosphate (SAPP), a food additive, is an inorganic compound. Disodium pyrophosphate has potential hematotoxic and immunotoxic effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Disodium pyrophosphate (oral administration, 12.6 mg/kg) displays hematotoxic and immunotoxic effects with long-term exposure in rats[1]. Animal Model: Adult Sprague-Dawley rats[1] Dosage: 12.6 mg/kg Administration: Oral administration Result: Displayed significant leukopenic condition. Decreased in CD3 T-lymphocyte and CD20 Blymphocyte immunolabeling in rats. Downregulated of PPAR-α and PPAR-γ together with upregulation of TNF-α.
References	[1]. Yasmina M Abd-Elhakim, et al. Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-α, PPAR-γ and tnfα signaling pathway. Environ Toxicol Pharmacol. 2018 Sep;62:98-106.

Density	2.311 g/cm3 (25ºC)
Melting Point	988ºC
Molecular Formula	H₂Na₂O₇P₂
Molecular Weight	221.93900
Exact Mass	221.90700
PSA	149.57000
LogP	0.06480
Stability	Stable.
Water Solubility	H2O: 0.1 M at 20 °C, clear, colorless

Disodium dihydrogen diphosphate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX6475000

CHEMICAL NAME :: Pyrophosphoric acid, disodium salt

CAS REGISTRY NUMBER :: 7758-16-9

LAST UPDATED :: 199707

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: H2-O7-P2.2Na

MOLECULAR WEIGHT :: 221.94

WISWESSER LINE NOTATION :: NA2 P2-O3-Q2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,47,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2309 No. of Facilities: 519 (estimated) No. of Industries: 15 No. of Occupations: 15 No. of Employees: 2961 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2309 No. of Facilities: 2180 (estimated) No. of Industries: 41 No. of Occupations: 39 No. of Employees: 48188 (estimated) No. of Female Employees: 9570 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UX6475000
HS Code	2835399000

HS Code	2835399000

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DISODIUM PYROPHOSPHATE

Disodium dihydrogen diphosphate

SAPP 28

SAPP

disodiumdiphosphate

DSPP

MFCD00014246

EINECS 231-835-0

SAPP 40

DisodiuM pytophospha

dinatriumpyrophosphat

Phosphonate, P,P'-oxybis-, sodium salt (1:2)

sodiumpyrophosphate,acid

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Disodium pyrophosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: potassium bicarbonate
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM CAS:7758-16-9 Disodium pytophosphate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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