Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Disodium pyrophosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM CAS:7758-16-9 Disodium pytophosphate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

7758-16-9

7758-16-9 structure

Name: Disodium dihydrogen diphosphate
Chemical Name: Disodium pytophosphate
CAS Number: 7758-16-9
Molecular Formula: H₂Na₂O₇P₂
Molecular Weight: 221.93900
Catalog: Inorganic chemical industry Inorganic salt Phosphides, metal phosphoric acid, metaphosphoric acid, hypophosphorous acid and pyrophosphate
Create Date: 2018-04-04 08:00:00
Modify Date: 2026-06-29 19:11:34
Disodium pyrophosphate (SAPP), a food additive, is an inorganic compound. Disodium pyrophosphate has potential hematotoxic and immunotoxic effects[1].

Name	Disodium pytophosphate
Synonyms	SODIUM DIHYDROGEN PYROPHOSPHATE SodiumAcidPyrophosphateFoodade disodiumacidpyrophosphate di-sodiumdihydrogenpyrophosphateanhydrous TIANFU-CHEM Disodium pytophosphate Food ade Sodium Acid Pyrophosphate SODIUM PYROPHOSPHATE DIBASIC BIOULTR SODIUMACIDPYROPHOSPHATE,FCC SAPP 40 Disodium (hydroxy-oxidophosphoryl) hydrogen phosphate disodiumdihydrogendiphosphate Sodium dihydrogen(acid) pyrophosphate Amyloid Precursor Protein α, Secreted human sodiumpyrophosphate,acid Disoduim dihydrogen pyrophosphate Diphosphoric acid disodium salt DISODIUM PYROPHOSPHATE SODIUM ACID PYROPHOSPHATE Sodium Pyrophosphate Acid Food ade Diphosphoric acid, sodium salt (1:2) Sodium pyrophosphate, di EINECS 231-835-0 Disodium dihydrogen pyrophosphate, Sodium diphosphate dibasic Sodium Acid Pyrophosphate (SAPP 28) Diphosphoric acid dihydrogen α,β-disodium salt Disodium dihydrogen pyrophosphate(SAPP) Sodium Pyrophosphate Buffer 0.2M, pH 7.0 SODIUM PYROPHOSPHATE SAPP 28 disodium pytophosphate DI-SODIUM DIHYDROGEN PYROPHOSPHATE sodiumpyrophosphate(na2h2p2o7) Na4P2O7.nH20 Sodium dihydrogen diphosphate(V) Sodium acidic pyrophosphate Amyloid Precursor Protein β, Secreted MFCD00014246 Dentin sialophosphoprotein Disodium pytophosphate //BP Sodium pyrophosphate dibasic PYROPHOSPHATE, DISODIUM PRACTICAL ADE DisodiuM pytophospha SodiuM pyrophosphate dibasic practical ade PYROPHOSPHATE DISODIUM SALT Phosphonate, P,P'-oxybis-, sodium salt (1:2) sodium acid pyrophosphate for food SODIUMHYDROGENPYROPHOSPHATE SAPP disodiumdiphosphate DSPP TwosodiuM pyrophosphatetwo hydrogen ANTI-DSPP (N-TERM) antibody produced in rabbit dinatriumpyrophosphat pyrophosphoricacid,disodiumsalt Sodium Acid Pyrophosphate (SAPP) extrapure

Description	Disodium pyrophosphate (SAPP), a food additive, is an inorganic compound. Disodium pyrophosphate has potential hematotoxic and immunotoxic effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Disodium pyrophosphate (oral administration, 12.6 mg/kg) displays hematotoxic and immunotoxic effects with long-term exposure in rats[1]. Animal Model: Adult Sprague-Dawley rats[1] Dosage: 12.6 mg/kg Administration: Oral administration Result: Displayed significant leukopenic condition. Decreased in CD3 T-lymphocyte and CD20 Blymphocyte immunolabeling in rats. Downregulated of PPAR-α and PPAR-γ together with upregulation of TNF-α.
References	[1]. Yasmina M Abd-Elhakim, et al. Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-α, PPAR-γ and tnfα signaling pathway. Environ Toxicol Pharmacol. 2018 Sep;62:98-106.

Density	2.311 g/cm3 (25ºC)
Melting Point	988ºC
Molecular Formula	H₂Na₂O₇P₂
Molecular Weight	221.93900
Exact Mass	221.90700
PSA	149.57000
LogP	0.06480
Stability	Stable.
Water Solubility	H2O: 0.1 M at 20 °C, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX6475000

CHEMICAL NAME :: Pyrophosphoric acid, disodium salt

CAS REGISTRY NUMBER :: 7758-16-9

LAST UPDATED :: 199707

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: H2-O7-P2.2Na

MOLECULAR WEIGHT :: 221.94

WISWESSER LINE NOTATION :: NA2 P2-O3-Q2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,47,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2309 No. of Facilities: 519 (estimated) No. of Industries: 15 No. of Occupations: 15 No. of Employees: 2961 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2309 No. of Facilities: 2180 (estimated) No. of Industries: 41 No. of Occupations: 39 No. of Employees: 48188 (estimated) No. of Female Employees: 9570 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UX6475000
HS Code	2835399000

HS Code	2835399000

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