Metoprine
Modify Date: 2025-08-21 19:27:26
Metoprine structure
|
Common Name | Metoprine | ||
|---|---|---|---|---|
| CAS Number | 7761-45-7 | Molecular Weight | 269.13000 | |
| Density | 1.447g/cm3 | Boiling Point | 483.7ºC at 760 mmHg | |
| Molecular Formula | C11H10Cl2N4 | Melting Point | 275-276ºC | |
| MSDS | N/A | Flash Point | 246.3ºC | |
Use of MetoprineMetoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT[1][2]. Metoprine is an antifolate and antitumor agent[3]. |
| Name | 5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine |
|---|---|
| Synonym | More Synonyms |
| Description | Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT[1][2]. Metoprine is an antifolate and antitumor agent[3]. |
|---|---|
| Related Catalog | |
| In Vivo | Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner[2]. Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption[1]. Animal Model: Male Sprague-dawley rats (200-280g)[2] Dosage: 2, 5, 10 mg/kg Administration: IP Result: Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg. |
| References |
| Density | 1.447g/cm3 |
|---|---|
| Boiling Point | 483.7ºC at 760 mmHg |
| Melting Point | 275-276ºC |
| Molecular Formula | C11H10Cl2N4 |
| Molecular Weight | 269.13000 |
| Flash Point | 246.3ºC |
| Exact Mass | 268.02800 |
| PSA | 77.82000 |
| LogP | 4.08560 |
| Index of Refraction | 1.678 |
| InChIKey | VQJHOPSWBGJHQS-UHFFFAOYSA-N |
| SMILES | Cc1nc(N)nc(N)c1-c1ccc(Cl)c(Cl)c1 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Hazard Codes | Xi |
|---|
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
|
|
Name: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum...
Source: The Scripps Research Institute Molecular Screening Center
Target: transactivating tegument protein VP16 [Human herpesvirus 1]
External Id: VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1
|
|
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Luminescence-based cell-based high throughput confirmation assay for inhibitors of th...
Source: The Scripps Research Institute Molecular Screening Center
Target: nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
External Id: SRC1_INH_LUMI_1536_3X%INH CRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
|
Total 360, Current Page 1 of 36
1
2
3
4
5
| METOPRINE,METHODICHLOROPHEN |
| BW-197U |
| 2aov |
| DDMP |
| METOPRINE |
| SK 5265 |
| Methodichlorophen |