CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UV8180000
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CHEMICAL NAME :
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Pyrimidine, 2,4-diamino-5-(3,4-dichlorophenyl)-6-methyl-
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CAS REGISTRY NUMBER :
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7761-45-7
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BEILSTEIN REFERENCE NO. :
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0223622
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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7
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MOLECULAR FORMULA :
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C11-H10-Cl2-N4
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MOLECULAR WEIGHT :
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269.15
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WISWESSER LINE NOTATION :
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T6N CNJ BZ DZ ER CG DG& F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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50 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Tumorigenic - active as anti-cancer agent
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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40 mg/kg/21D-I
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TOXIC EFFECTS :
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Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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2500 ug/kg
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SEX/DURATION :
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female 7 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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5 mg/kg
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SEX/DURATION :
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female 8-9 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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7500 ug/kg
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SEX/DURATION :
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female 6-8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
MUTATION DATA
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TEST SYSTEM :
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Human
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DOSE/DURATION :
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2800 ug/kg
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REFERENCE :
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RBBIAL Revista Brasileira de Biologia. Brazilian Review of Biology. (Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro, Brazil) V.1- 1941- Volume(issue)/page/year: 25,145,1965
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