Bis-PEG6-acid

Modify Date: 2024-01-08 16:11:21

Bis-PEG6-acid Structure
Bis-PEG6-acid structure
Common Name Bis-PEG6-acid
CAS Number 77855-76-6 Molecular Weight 354.35
Density N/A Boiling Point N/A
Molecular Formula C14H26O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bis-PEG6-acid


PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1].

 Names

Name PEG6-(CH2CO2H)2

 Bis-PEG6-acid Biological Activity

Description PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1].
Related Catalog
Target

PROTAC linker[1]

References

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

 Chemical & Physical Properties

Molecular Formula C14H26O10
Molecular Weight 354.35

 Safety Information

Hazard Codes Xi
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