2′-Deoxy-2′-fluoroguanosine

Modify Date: 2024-01-03 10:10:04

2′-Deoxy-2′-fluoroguanosine Structure
2′-Deoxy-2′-fluoroguanosine structure
 Common Name 2′-Deoxy-2′-fluoroguanosine
CAS Number 78842-13-4 Molecular Weight 285.232
Density 2.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C10H12FN5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2′-Deoxy-2′-fluoroguanosine


2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2].

 Names

Name 2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonym More Synonyms

 2′-Deoxy-2′-fluoroguanosine Biological Activity

Description 2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2].
Related Catalog
Target

EC90: <0.35 μM (influenza virus A and B)[1]

References

[1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.

[2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.

 Chemical & Physical Properties

Density 2.2±0.1 g/cm3
Molecular Formula C10H12FN5O4
Molecular Weight 285.232
Exact Mass 285.087341
PSA 140.27000
LogP -0.53
Appearance of Characters Powder | White to Off-white
Index of Refraction 1.876

 Safety Information

Hazard Codes Xn
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2'-fluorodeoxyguanisine
2'-Fluoro-2'-deoxyguanosine
2'-fluorodeoxyguanosine
2'-fluoro guanosine
2'-fluoro-2',3'-dideoxyguanosine
2'-Dfgs
2'-Deoxy-2'-fluoroguanosine
Guanosine,2'-deoxy-2'-fluoro
Guanosine, 2'-deoxy-2'-fluoro-
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