idoxuridine

Modify Date: 2025-08-21 11:10:00

idoxuridine structure	Common Name	idoxuridine
	CAS Number	54-42-2	Molecular Weight	354.099
	Density	2.1±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁IN₂O₅	Melting Point	194 °C(lit.)
	MSDS	USA	Flash Point	N/A
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of idoxuridine

Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.

Name	5-iodo-2'-deoxyuridine
Synonym	More Synonyms

Description	Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
References	[1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89. [2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56. [3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

References

[1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89.

[2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56.

[3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7.

Density	2.1±0.1 g/cm3
Melting Point	194 °C(lit.)
Molecular Formula	C₉H₁₁IN₂O₅
Molecular Weight	354.099
Exact Mass	353.971252
PSA	104.55000
LogP	-0.52
Index of Refraction	1.715
Water Solubility	1.6 g/L (20 ºC)

idoxuridine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7700000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-iodo-

CAS REGISTRY NUMBER :: 54-42-2

BEILSTEIN REFERENCE NO. :: 0030397

LAST UPDATED :: 199806

DATA ITEMS CITED :: 37

MOLECULAR FORMULA :: C9-H11-I-N2-O5

MOLECULAR WEIGHT :: 354.12

WISWESSER LINE NOTATION :: T6NVMVJ EI A- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4589 mg/kg/18D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 mg/kg

SEX/DURATION :: female 16-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 300 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

DOSE :: 1350 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

DOSE :: 3250 ug/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rabbit Kidney

DOSE/DURATION :: 1 mg/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,390,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5053 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 618 (estimated) No. of Female Employees: 318 (estimated)

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H335-H341-H361
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R45;R46;R61
Safety Phrases	S53-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YU7700000
HS Code	2934999090

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((2R,3S,5R)-3-A...

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2'-deoxyuridine

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Precursor 8
CAS#:951-78-0 2'-deoxyuridine CAS#:696-07-1 5-Iodouracil CAS#:1956-30-5 ((2R,3S,5R)-3-A... CAS#:65505-76-2 5-chloromercuri...
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DownStream 10
CAS#:951-78-0 2'-deoxyuridine CAS#:50-90-8 5-Chloro-2'-deo... CAS#:144989-71-9 1-[(2R,4S,5R)-5... CAS#:92233-50-6 Aids186752
CAS#:37972-24-0 2-Ethynylpyrimidine CAS#:1956-30-5 ((2R,3S,5R)-3-A... CAS#:215668-76-1 5-dodec-1-ynyl-... CAS#:36792-88-8 2-Deoxy-β-D-rib...
CAS#:696-07-1 5-Iodouracil CAS#:66-22-8 Uracil

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

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Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

5-Iodo-2'-desoxyuridine

UNII-LGP81V5245

Dendrid (Trade name)

5-Iodo-2'-Deoxyuridine

Idoxene

Idulea

1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-iodo-2,4(1H,3H)-pyrimidinedione

idoxuridine

STOXIL

Ophthalmadine

HERPLEX

Uracil, 5-iodo-1-(2-deoxy-β-D-ribofuranosyl)-

EINECS 200-207-8

1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodpyrimidin-2,4(1H,3H)-dion

Kerecid

2′-Deoxy-5-iodouridine

2'-Deoxy-5-iodouridine

Virudox

Uridine, 2'-deoxy-5-iodo-

5-Iodo-2′-deoxyuridine

MFCD00134656

Iduridin

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China
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DC Chemicals Limited
China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Idoxuridine
Price: ￥Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (+)-5-Iodo-2'-deoxyuridine
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM CAS:54-42-2 (+)-5-Iodo-2'-deoxyuridine
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Purity: 99.0%
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Email: info@tianfuchem.com

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idoxuridine

Use of idoxuridine

Names

idoxuridine Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

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