idoxuridine

Modify Date: 2026-07-01 17:30:31

idoxuridine structure	Common Name	idoxuridine
	CAS Number	54-42-2	Molecular Weight	354.099
	Density	2.1±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁IN₂O₅	Melting Point	194 °C(lit.)
	MSDS	USA	Flash Point	N/A
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of idoxuridine

Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	5-iodo-2'-deoxyuridine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
References	[1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89. [2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56. [3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

References

[1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89.

[2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56.

[3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	2.1±0.1 g/cm3
Melting Point	194 °C(lit.)
Molecular Formula	C₉H₁₁IN₂O₅
Molecular Weight	354.099
Exact Mass	353.971252
PSA	104.55000
LogP	-0.52
Index of Refraction	1.715
InChIKey	XQFRJNBWHJMXHO-RRKCRQDMSA-N
SMILES	O=c1[nH]c(=O)n(C2CC(O)C(CO)O2)cc1I
Water Solubility	1.6 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

idoxuridine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7700000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-iodo-

CAS REGISTRY NUMBER :: 54-42-2

BEILSTEIN REFERENCE NO. :: 0030397

LAST UPDATED :: 199806

DATA ITEMS CITED :: 37

MOLECULAR FORMULA :: C9-H11-I-N2-O5

MOLECULAR WEIGHT :: 354.12

WISWESSER LINE NOTATION :: T6NVMVJ EI A- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4589 mg/kg/18D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 mg/kg

SEX/DURATION :: female 16-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 300 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

DOSE :: 1350 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

DOSE :: 3250 ug/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rabbit Kidney

DOSE/DURATION :: 1 mg/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,390,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5053 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 618 (estimated) No. of Female Employees: 318 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H335-H341-H361
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R45;R46;R61
Safety Phrases	S53-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YU7700000
HS Code	2934999090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

2'-deoxyuridine

CAS#:951-78-0

5-Iodouracil

CAS#:696-07-1

idoxuridine

CAS#:54-42-2

Uracil

CAS#:66-22-8

Learn More

Literature: Journal of Molecular Catalysis B: Enzymatic, , vol. 95, p. 16 - 22

2'-deoxyuridine

CAS#:951-78-0

~96%

idoxuridine

CAS#:54-42-2

Learn More

Literature: Kumar; Wiebe; Knaus Canadian Journal of Chemistry, 1994 , vol. 72, # 9 p. 2005 - 2010

((2R,3S,5R)-3-A...

CAS#:1956-30-5

~92%

idoxuridine

CAS#:54-42-2

Learn More

Literature: Asakura, Jun-ichi; Robins, Morris J. Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933

5-chloromercuri...

CAS#:65505-76-2

1,3,4,6-Tetrach...

CAS#:51592-06-4

idoxuridine

CAS#:54-42-2

Learn More

Literature: US4851520 A1, ;

5-Iodouracil

CAS#:696-07-1

Thymidine

CAS#:50-89-5

~90%

idoxuridine

CAS#:54-42-2

Thymine

CAS#:65-71-4

Learn More

Literature: Hatano, Akihiko; Harano, Aiko; Kirihara, Masayuki Chemistry Letters, 2006 , vol. 35, # 2 p. 232 - 233

3,5'-Di-O-acety...

CAS#:13030-62-1

idoxuridine

CAS#:54-42-2

Learn More

Literature: Journal of Organic Chemistry, , vol. 55, # 16 p. 4928 - 4933

5-(TriMethylsta...

CAS#:146629-34-7

idoxuridine

CAS#:54-42-2

Learn More

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 34, # 6 p. 513 - 522

2'-deoxyuridine

CAS#:951-78-0

5-Iodouracil

CAS#:696-07-1

idoxuridine

CAS#:54-42-2

Learn More

Literature: Collection of Czechoslovak Chemical Communications, , vol. 59, # 10 p. 2303 - 2330

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:951-78-0 2'-deoxyuridine CAS#:696-07-1 5-Iodouracil CAS#:1956-30-5 ((2R,3S,5R)-3-A... CAS#:65505-76-2 5-chloromercuri...
CAS#:51592-06-4 1,3,4,6-Tetrach... CAS#:50-89-5 Thymidine CAS#:13030-62-1 3,5'-Di-O-acety... CAS#:146629-34-7 5-(TriMethylsta...
DownStream 10
CAS#:951-78-0 2'-deoxyuridine CAS#:50-90-8 5-Chloro-2'-deo... CAS#:144989-71-9 1-[(2R,4S,5R)-5... CAS#:92233-50-6 Aids186752
CAS#:37972-24-0 2-Ethynylpyrimidine CAS#:1956-30-5 ((2R,3S,5R)-3-A... CAS#:215668-76-1 5-dodec-1-ynyl-... CAS#:36792-88-8 2-Deoxy-β-D-rib...
CAS#:696-07-1 5-Iodouracil CAS#:66-22-8 Uracil

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

5-Iodo-2'-desoxyuridine

UNII-LGP81V5245

Dendrid (Trade name)

5-Iodo-2'-Deoxyuridine

Idoxene

Idulea

1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-iodo-2,4(1H,3H)-pyrimidinedione

idoxuridine

STOXIL

Ophthalmadine

HERPLEX

EINECS 200-207-8

1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodpyrimidin-2,4(1H,3H)-dion

Kerecid

2′-Deoxy-5-iodouridine

2'-Deoxy-5-iodouridine

Virudox

5-Iodo-2′-deoxyuridine

MFCD00134656

Iduridin

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of 5-iodo-2'-deoxyuridine?

A: The English name of 5-iodo-2'-deoxyuridine is 5-iodo-2'-deoxyuridine.

Q: What English synonyms does 5-iodo-2'-deoxyuridine have?

A: English synonyms of 5-iodo-2'-deoxyuridine: 5-Iodo-2'-desoxyuridine, UNII-LGP81V5245, Dendrid (Trade name), 5-Iodo-2'-Deoxyuridine, Idoxene, Idulea, 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-iodo-2,4(1H,3H)-pyrimidinedione, idoxuridine, STOXIL, Ophthalmadine, HERPLEX, EINECS 200-207-8, 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodpyrimidin-2,4(1H,3H)-dion, Kerecid, 2′-Deoxy-5-iodouridine, 2'-Deoxy-5-iodouridine, Virudox, 5-Iodo-2′-deoxyuridine, MFCD00134656, Iduridin.

Q: What is the polar surface area (PSA) of 5-iodo-2'-deoxyuridine?

A: Polar surface area (PSA) of 5-iodo-2'-deoxyuridine is 104.55000.

Q: How is the water solubility of 5-iodo-2'-deoxyuridine?

A: Water solubility of 5-iodo-2'-deoxyuridine: 1.6 g/L (20 ºC).

Q: What are the uses of 5-iodo-2'-deoxyuridine?

A: Main uses of 5-iodo-2'-deoxyuridine: Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.

Q: What is the LogP of 5-iodo-2'-deoxyuridine?

A: LogP of 5-iodo-2'-deoxyuridine is -0.52.

Q: What are the downstream products of 5-iodo-2'-deoxyuridine?

A: Related downstream products(CAS) of 5-iodo-2'-deoxyuridine: 951-78-0;50-90-8;144989-71-9;92233-50-6;37972-24-0;1956-30-5;215668-76-1;36792-88-8;696-07-1;66-22-8.

Q: What is the InChIKey of 5-iodo-2'-deoxyuridine?

A: InChIKey of 5-iodo-2'-deoxyuridine is XQFRJNBWHJMXHO-RRKCRQDMSA-N.

Q: What is the CAS number of 5-iodo-2'-deoxyuridine?

A: CAS number of 5-iodo-2'-deoxyuridine is 54-42-2.

Q: What are the upstream materials of 5-iodo-2'-deoxyuridine?

A: Related upstream materials(CAS) of 5-iodo-2'-deoxyuridine: 951-78-0;696-07-1;1956-30-5;65505-76-2;51592-06-4;50-89-5;13030-62-1;146629-34-7.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: idoxuridine
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (+)-5-Iodo-2'-deoxyuridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM CAS:54-42-2 (+)-5-Iodo-2'-deoxyuridine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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idoxuridine Biological Activity

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