2'-氟-2'-脱氧鸟苷

• 常用名: 2'-氟-2'-脱氧鸟苷
• 英文名: 2′-Deoxy-2′-fluoroguanosine
• CAS号: 78842-13-4
• 分子量: 285.232
• 密度: 2.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₁₂FN₅O₄
• 熔点: N/A
• 闪点: N/A

2'-氟-2'-脱氧鸟苷用途

2′-Deoxy-2′-fluoroguanosine,一种核苷类似物,是有效的流感病毒 (influenza virus) 抑制剂,抑制 A 型和 B 型流感病毒的 EC90 值 <0.35 μM。2′-Deoxy-2′-fluoroguanosine 可显着抑制流感病毒在上呼吸道中的复制,从而改善发烧和鼻腔炎症。

2'-氟-2'-脱氧鸟苷名称

• 中文名: 2'-氟-2'-脱氧鸟苷
• 英文名: 2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

2'-氟-2'-脱氧鸟苷生物活性

• 描述: 2′-Deoxy-2′-fluoroguanosine,一种核苷类似物,是有效的流感病毒 (influenza virus) 抑制剂,抑制 A 型和 B 型流感病毒的 EC90 值 <0.35 μM。2′-Deoxy-2′-fluoroguanosine 可显着抑制流感病毒在上呼吸道中的复制,从而改善发烧和鼻腔炎症。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 靶点实验:

  EC90: <0.35 μM (influenza virus A and B)[1]

• 参考文献:

  [1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.

  [2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.

2'-氟-2'-脱氧鸟苷物理化学性质

• 密度: 2.2±0.1 g/cm3
• 分子式: C₁₀H₁₂FN₅O₄
• 分子量: 285.232
• 精确质量: 285.087341
• PSA: 140.27000
• LogP: -0.53
• 外观性状: Powder | White to Off-white
• 折射率: 1.876
• 储存条件: 室温

2'-氟-2'-脱氧鸟苷安全信息

• 危害码 (欧洲): Xn
• 海关编码: 2934999090

2'-氟-2'-脱氧鸟苷海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2'-氟-2'-脱氧鸟苷靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Inhibition HCV RNA replication 来源：ChEMBL 靶标：RNA-directed RNA polymerase External Id：CHEMBL691888

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Compound was evaluated for inhibition HCV NS5B-mediated RNA synthesis; Substrate 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL691890

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DM... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4296191

实验名称：Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3428605

实验名称：Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MI... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL4296188

实验名称：Inhibition of human mitochondrial DNA polymerase gamma large subunit/DNA polymerase g... 来源：ChEMBL 靶标：DNA polymerase subunit gamma-2, mitochondrial External Id：CHEMBL3428608

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4296187

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2'-氟-2'-脱氧鸟苷英文别名

• 2'-fluorodeoxyguanisine
• 2'-Fluoro-2'-deoxyguanosine
• 2'-fluorodeoxyguanosine
• 2'-fluoro guanosine
• 2'-fluoro-2',3'-dideoxyguanosine
• 2'-Dfgs
• 2'-Deoxy-2'-fluoroguanosine
• Guanosine,2'-deoxy-2'-fluoro