α-Terpinyl acetate

Modify Date: 2024-01-03 08:40:50

α-Terpinyl acetate structure	Common Name	α-Terpinyl acetate
	CAS Number	80-26-2	Molecular Weight	196.286
	Density	1.0±0.1 g/cm3	Boiling Point	239.9±9.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₂₀O₂	Melting Point	220 °C
	MSDS	Chinese USA	Flash Point	83.0±17.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of α-Terpinyl acetate

α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM[1][2].

Name	Terpinyl Acetate
Synonym	More Synonyms

Description	α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease
Target	CYP2B6:5.4  μM (Kd)
In Vitro	The bupropion hydroxylation activity of P450 2B6 is inhibited by α-Terpinyl acetate wiht an IC50 value of 10.4 μM and α-Terpinyl acetate is determined to be a competitive inhibitor of P450 2B6 with a Ki of 7.6  μM[2].
References	[1]. Fidan H, et al. Chemical Composition and Antimicrobial Activity of Laurus nobilis L. Essential Oils from Bulgaria. Molecules. 2019 Feb 22;24(4). [2]. Lee Y, et al. Inhibitory effect of α-terpinyl acetate on cytochrome P450 2B6 enzymatic activity. Chem Biol Interact. 2018 Jun 1;289:90-97.

Density	1.0±0.1 g/cm3
Boiling Point	239.9±9.0 °C at 760 mmHg
Melting Point	220 °C
Molecular Formula	C₁₂H₂₀O₂
Molecular Weight	196.286
Flash Point	83.0±17.1 °C
Exact Mass	196.146332
PSA	26.30000
LogP	3.67
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.467

α-Terpinyl acetate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OT0200000

CHEMICAL NAME :: p-Menth-1-en-8-ol, acetate

CAS REGISTRY NUMBER :: 80-26-2

BEILSTEIN REFERENCE NO. :: 3198769

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H20-O2

MOLECULAR WEIGHT :: 196.32

WISWESSER LINE NOTATION :: L6UTJ A DXOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5075 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >1 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 mg/m3/4H/17W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2063 No. of Facilities: 4671 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 44114 (estimated) No. of Female Employees: 28016 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	OT0200000
HS Code	2915390090

Precursor 0
DownStream 8
CAS#:586-62-9 Terpinolene CAS#:99-86-5 alpha-Terpinene CAS#:5989-54-8 (S)-(-)-Limonene CAS#:10482-56-1 Alpha-Terpineol
CAS#:19894-91-8 (S)-4-(1-hydrox... CAS#:83921-01-1 (+/-)-5-(1-hydr... CAS#:83921-04-4 (4S)-8-acetoxy-... CAS#:83946-42-3 (1R,2R,4S)-8-ac...

HS Code	2915390090
Summary	2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

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MFCD00037155

a-terpinyl acetate, (±)

(±)-α-Terpineol acetate

EINECS 201-265-7

2-(4-Methyl-3-cyclohexen-1-yl)-2-propyl acetate

2-(4-Methyl-3-cyclohexen-1-yl)-2-propanyl acetate

p-Menth-1-en-8-ol acetate

3-Cyclohexene-1-methanol, α,α,4-trimethyl-, acetate

(±)-2-(4-Methyl-3-cyclohexen-1-yl)-2-propanylacetat

1-Methyl-1-(4-methylcyclohex-3-en-1-yl)ethyl acetate

L6UTJ A1 DX1&1&OV1

Terpinyl acetate

(±)-a-Terpinyl acetate

p-Menth-1-en-8-ol, acetate

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Terpinyl acetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Terpinyl acetate
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: CAS 80-26-2 Terpinyl acetate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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α-Terpinyl acetate Biological Activity

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MSDS