Endovalpin

Modify Date: 2025-08-27 11:26:51

Endovalpin structure	Common Name	Endovalpin
	CAS Number	80-50-2	Molecular Weight	525.63200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₄₃NO₉	Melting Point	329ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Endovalpin

Anisotropine methobromide is an orally active anticholinergic muscarinic antagonist. Anisotropine methobromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers[1].

Name	anisotropine methylbromide
Synonym	More Synonyms

Description	Anisotropine methobromide is an orally active anticholinergic muscarinic antagonist. Anisotropine methobromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Metabolic Disease
In Vivo	Anisotropine methobromide (intravenous injection, 0.5 μM and 0.1 mL, once) can block acetylcholine-induced vocalization, intestinal spasm and intestinal contractions in conscious or anesthetized dogs[1]. Animal Model: Dogs weighing 2.5 to 5.0 kg[1] Dosage: 0.5 μM, 0.1 mL Administration: Intravenous injection; once Result: Inhibited the acetylcholine-induced vocalization with maximum inhibition of 85.1% and the acetylcholine-induced intestinal spasm with maximum inhibition of 79%.
References	[1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20.

Melting Point	329ºC
Molecular Formula	C₂₇H₄₃NO₉
Molecular Weight	525.63200
Exact Mass	525.29400
PSA	174.31000
InChIKey	QSFKGMJOKUZAJM-UHFFFAOYSA-M
SMILES	CCCC(CCC)C(=O)OC1CC2CCC(C1)[N+]2(C)C.[Br-]
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3710000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropanium, 3-alpha-hydroxy-8-methyl-, bromide, 2-propylvalerate

CAS REGISTRY NUMBER :: 80-50-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H32-N-O2.Br

MOLECULAR WEIGHT :: 362.41

WISWESSER LINE NOTATION :: T56 A AKTJ A1 A1 GOVY3&3 &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 705 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2759 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 197 (estimated) No. of Female Employees: 59 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H312-H332-H400
Precautionary Statements	P273-P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;N: Dangerous for the environment;
Risk Phrases	R20/21/22
Safety Phrases	36-61-60
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	YM3710000

[Pediatric use of a drug, anticholinergic and muscle relaxant on the gastrointestinal tract].

Pediatr. Med. Chir. 4(1-2) , 79-81, (1982)

[Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study].

ZFA (Stuttgart.) 58(27) , 1481-4, (1982)

[Preliminary clinical research on a new anti-ulcer drug].

Clin. Ter. 89(4) , 365-71, (1979)

Name: qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali...
Source: NCGC
External Id: adst_MBL_Abs_LOPAC_o1

Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315

Name: qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus...
Source: NCGC
Target: N/A
External Id: ZIK097

Name: High throughput screen for small molecule inhibitors of a hypoxia-regulated fluoresce...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1149-MLP

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS1303

Name: Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase...
Source: NCGC
External Id: GPx1-biochemical-p4-p7

Name: Validation qHTS for Identification of Calcium Integrin Binding protein 1 (CIB1) Compe...
Source: NCGC
External Id: cib1-v1-fp-lopac

Name: qHTS assay to identify small molecule antagonists of the estrogen related receptor (E...
Source: 824
Target: N/A
External Id: ERR513

Name: qHTS assay to identify small molecule antagonists of the estrogen related receptor (E...
Source: 824
External Id: ERR845

Total 29, Current Page 1 of 3

octatropine methylbromide

Methoxy(benzene-2,4,6-d3)

Anisole-2,4,6-d3

1,3,5-trideuterio-2-methoxy-benzene

CHOLINE IODIDE 1-HYDROXY-α-PHENYLCYCLOPENTANEACETATE

2,4,6-Trideutero-anisol

anisotropine methobromide

2,4,6-Trideuterio-anisol

anisotropine methyl bromide

2,4,6-trideuterioanisole

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Anisotropine Methylbromide
Price: Check
Purity: 99.73%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: octatropine methylbromide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Endovalpin Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Articles5

EndovalpinBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.