溴甲辛托品

• 常用名: 溴甲辛托品
• 英文名: Endovalpin
• CAS号: 80-50-2
• 分子量: 525.63200
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₄₃NO₉
• 熔点: 329ºC
• 闪点: N/A
• 符号: GHS07, GHS09
• 信号词: Warning

溴甲辛托品用途

甲溴化异丙肾上腺素是一种口服活性抗胆碱能毒蕈碱拮抗剂。甲溴化异丙肾上腺素可抑制胃酸分泌,并用作消化性溃疡的辅助药物[1]。

溴甲辛托品名称

• 中文名: 溴甲辛托品
• 英文名: anisotropine methylbromide
• 中文别名: O-乙酰基-L-肉碱盐酸盐 | 甲溴辛托品

溴甲辛托品生物活性

• 描述: 甲溴化异丙肾上腺素是一种口服活性抗胆碱能毒蕈碱拮抗剂。甲溴化异丙肾上腺素可抑制胃酸分泌,并用作消化性溃疡的辅助药物[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 代谢疾病
• 体内研究: 甲溴化异丙肾上腺素(静脉注射,0.5μM和0.1ml,一次)可阻断清醒或麻醉狗的乙酰胆碱诱导的发声、肠痉挛和肠收缩[1]。动物模型：体重2.5-5.0kg的狗[1]剂量：0.5μM,0.1ml给药：静脉注射；一次结果：抑制乙酰胆碱诱导的发声,最大抑制率为85.1%,抑制乙酰胆碱酯酶诱导的肠痉挛,最大抑制为79%。
• 参考文献:

  [1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20.

溴甲辛托品物理化学性质

• 熔点: 329ºC
• 分子式: C₂₇H₄₃NO₉
• 分子量: 525.63200
• 精确质量: 525.29400
• PSA: 174.31000
• InChIKey: QSFKGMJOKUZAJM-UHFFFAOYSA-M
• SMILES: CCCC(CCC)C(=O)OC1CC2CCC(C1)[N+]2(C)C.[Br-]
• 储存条件: 2-8°C

溴甲辛托品毒性和生态

溴甲辛托品安全信息

• 符号: GHS07, GHS09
• 信号词: Warning
• 危害声明: H302-H312-H332-H400
• 警示性声明: P273-P280
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;N: Dangerous for the environment;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 36-61-60
• 危险品运输编码: UN 3077 9/PG 3
• WGK德国: 3
• RTECS号: YM3710000

溴甲辛托品靶点实验

查看更多实验

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus... 来源：NCGC 靶标：N/A External Id：ZIK097

实验名称：High throughput screen for small molecule inhibitors of a hypoxia-regulated fluoresce... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1149-MLP

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Validation qHTS for Identification of Calcium Integrin Binding protein 1 (CIB1) Compe... 来源：NCGC External Id：cib1-v1-fp-lopac

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 靶标：N/A External Id：ERR513

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 External Id：ERR845

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溴甲辛托品英文别名

• octatropine methylbromide
• Methoxy(benzene-2,4,6-d3)
• Anisole-2,4,6-d3
• 1,3,5-trideuterio-2-methoxy-benzene
• CHOLINE IODIDE 1-HYDROXY-α-PHENYLCYCLOPENTANEACETATE
• 2,4,6-Trideutero-anisol
• anisotropine methobromide
• 2,4,6-Trideuterio-anisol
• anisotropine methyl bromide
• 2,4,6-trideuterioanisole