ABT-102

Modify Date: 2024-01-02 23:18:02

ABT-102 Structure
ABT-102 structure
 Common Name ABT-102
CAS Number 808756-71-0 Molecular Weight 348.44
Density 1.24 g/cm3 Boiling Point 529.5ºC at 760 mmHg
Molecular Formula C21H24N4O Melting Point N/A
MSDS N/A Flash Point 274.1ºC

 Use of ABT-102


ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2].

 Names

Name 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-(1H-indazol-4-yl)urea
Synonym More Synonyms

 ABT-102 Biological Activity

Description ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2].
Related Catalog
Target

TRPV1
References

[1]. Lukin K, et al. Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102. Organic Process Research & Development, 2007, 11(3):578-584.

[2]. Rowbotham MC, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011 May;152(5):1192-1200.  

 Chemical & Physical Properties

Density 1.24 g/cm3
Boiling Point 529.5ºC at 760 mmHg
Molecular Formula C21H24N4O
Molecular Weight 348.44
Flash Point 274.1ºC
Exact Mass 348.19500
PSA 69.81000
LogP 5.13330
Storage condition 2-8°C

 Synthetic Route

N/A structure

N/A

CAS#:952734-48-4

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Lukin, Kirill A.; Hsu, Margaret Chi-Ping; Fernando, Dilinie P.; Kotecki, Brian J.; Leanna, Marvin R. Patent: US2007/244178 A1, 2007 ; Location in patent: Page/Page column 14 ;
methyl 4-[({[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]amino}carbonyl)amino]-1H-indazole-1-carboxylate structure

methyl 4-[({[(1...

CAS#:808756-69-6

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Surowy, Carol S.; Honore, Prisca; Marsh, Kennan C.; Hannick, Steven M.; McDonald, Heath A.; Wetter, Jill M.; Sullivan, James P.; Jarvis, Michael F.; Faltynek, Connie R.; Lee, Chih-Hung Journal of Medicinal Chemistry, 2008 , vol. 51, # 3 p. 392 - 395
N/A structure

N/A

CAS#:253185-03-4

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
1-(4-t-Butylphenyl)-3-chloropropan-1-one structure

1-(4-t-Butylphe...

CAS#:28547-33-3

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
5-(tert-Butyl)-2,3-dihydro-1H-inden-1-one structure

5-(tert-Butyl)-...

CAS#:4600-86-6

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
5-tert-butyl-2,3-dihydro-1H-inden-1-amine structure

5-tert-butyl-2,...

CAS#:935680-90-3

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
4-(2,5-dioxopyrrolidin-1-yl-oxycarbonylamino)indazole-1-carboxylic acid methyl ester structure

4-(2,5-dioxopyr...

CAS#:735330-50-4
(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-amine,4-methylbenzenesulfonic acid structure

(1R)-5-tert-but...

CAS#:934593-36-9

~%

ABT-102 Structure

ABT-102

CAS#:808756-71-0
Literature: Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

 Synonyms

N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea
(R)-1-(5-tert-butylindan-1-yl)-3-(1H-indazol-4-yl)
ABT-102
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Chemsrc provides ABT-102(CAS#:808756-71-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ABT-102 are included as well.>> amp version: ABT-102

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