PTP1B-IN-3
Modify Date: 2025-08-21 21:37:37
PTP1B-IN-3 structure
|
Common Name | PTP1B-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 809272-64-8 | Molecular Weight | 362.06300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H7BrF2NO3P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PTP1B-IN-3PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively. |
| Name | [(3-bromo-7-cyano-2-naphthyl)-(difluoro)methyl]phosphonic acid |
|---|---|
| Synonym | More Synonyms |
| Description | PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 120 nM (PTP1B), 120 nM (TCPTP) [1]. |
| References |
| Molecular Formula | C12H7BrF2NO3P |
|---|---|
| Molecular Weight | 362.06300 |
| Exact Mass | 360.93100 |
| PSA | 91.13000 |
| LogP | 3.70098 |
| InChIKey | BWJOQFMMTKEZGA-UHFFFAOYSA-N |
| SMILES | N#Cc1ccc2cc(Br)c(C(F)(F)P(=O)(O)O)cc2c1 |
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Name: Oral bioavailability in Squirrel monkey at 5 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Saimiri sciureus
External Id: CHEMBL936473
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Name: Inhibition of PTP1B (unknown origin)
Source: ChEMBL
Target: Tyrosine-protein phosphatase non-receptor type 1
External Id: CHEMBL5616320
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Name: Elimination half life in Squirrel monkey at 5 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Saimiri sciureus
External Id: CHEMBL936474
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Name: Inhibition of PTPN2 (unknown origin)
Source: ChEMBL
Target: Tyrosine-protein phosphatase non-receptor type 2
External Id: CHEMBL5616321
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Name: Clearance in Squirrel monkey at 5 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Saimiri sciureus
External Id: CHEMBL936475
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|
Name: Inhibition of PTP1B
Source: ChEMBL
Target: Tyrosine-protein phosphatase non-receptor type 1
External Id: CHEMBL1767946
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Name: Oral bioavailability in rat at 5 mg/kg, iv and 20 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL936468
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|
Name: Elimination half life in rat at 5 mg/kg, iv and 20 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL936469
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|
Name: Clearance in rat at 5 mg/kg, iv and 20 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL936470
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|
Name: Inhibition of glucose excursion in DIO mouse glucose challenged 2 hrs before the test...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL936480
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| P-[(3-Bromo-7-cyano-2-naphthalenyl)difluoromethyl]phosphonic Acid |
| PTP1B-IN-3 |