cholic acid structure
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Common Name | cholic acid | ||
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CAS Number | 81-25-4 | Molecular Weight | 408.571 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 583.9±50.0 °C at 760 mmHg | |
Molecular Formula | C24H40O5 | Melting Point | 197-202 ºC | |
MSDS | Chinese USA | Flash Point | 321.0±26.6 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of cholic acidCholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. |
Name | cholic acid |
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Synonym | More Synonyms |
Description | Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. |
In Vivo | Cholic acid feeding leads to increased CYP2D6 expression in CYP2D6-humanized mice. As a cholestasis model, Tg-CYP2D6 mice are fed a Cholic acid (CA)-supplemented diet for over 1 week. The treatment is known to increase bile acid pool size by 2-fold and to replace ~90% of bile acids with CA, recapitulating the features of cholestatic conditions in humans[2]. |
Cell Assay | HepG2 cells are pretreated with the inhibitors NaN3 (1 mg/mL), Genistein (50 μg/mL), MβCD (10 mM), Nystatin (50 μg/mL), Chlorpromazine (10 μg/mL), and Cholic acid (1 mg/mL) for 30 min. After removing the inhibitors, the cells are incubated with CA-LPs for 2 h, and the cellular uptake of LPs is determined in the "In vitro cellular uptake assays" section[1]. |
Animal Admin | Mice[2] Tg-CYP2D6 mice are fed with normal chow (control) or 1% (w/w) Cholic acid-supplemented diet (CA) for 14 days (n=4 mice/group). Alkaline phosphatase (ALP) and alanine aminotransferase (ALT) activities are measured in mouse serum. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 583.9±50.0 °C at 760 mmHg |
Melting Point | 197-202 ºC |
Molecular Formula | C24H40O5 |
Molecular Weight | 408.571 |
Flash Point | 321.0±26.6 °C |
Exact Mass | 408.287567 |
PSA | 97.99000 |
LogP | 2.62 |
Vapour Pressure | 0.0±3.7 mmHg at 25°C |
Index of Refraction | 1.558 |
Storage condition | 2-8°C |
Water Solubility | 0.28 g/L (15 ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319 |
Precautionary Statements | P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | Xi |
Risk Phrases | R36/37/38 |
Safety Phrases | S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
RTECS | FZ9350000 |
HS Code | 2942000000 |
Precursor 8 | |
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DownStream 10 | |
HS Code | 2942000000 |
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Tunable stringency aptamer selection and gold nanoparticle assay for detection of cortisol.
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Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
Antimicrob. Agents Chemother. 54 , 1007-15, (2010) AcrAB-TolC imparts a strong intrinsic resistance phenotype to many clinically significant molecules in Escherichia coli. This complex is composed of a pump, AcrB, and a periplasmic protein, AcrA, that... |
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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.
Antimicrob. Agents Chemother. 51 , 923-9, (2007) AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and... |
Cholalic acid |
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)- (9CI) |
cholic acid |
17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7a,12a-triol |
3a,7a,12a-Trihydroxycholanic acid |
5β-Cholic acid |
3a,7a,12a-Trihydroxy-5b-cholanoic acid |
(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
5b-Cholic acid |
3a,7a,12a-Trihydroxy-5b-cholanic Acid |
3α,7α,12α-trihydroxy-5β-cholan-24-oic acid |
CHOLALIN |
MFCD00003672 |
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,8ξ,12α,20R)- |
EINECS 201-337-8 |
Cholbam |
Cholic&Cyclosphorine |
3a,7a,12a-Trihydroxy-b-cholanic acid |
3a,7a,12a-Trihydroxy-β-cholanic acid |
Cholic acd |
5b-Cholanic acid-3a,7a,12a-triol |
AHR 3053-13C3 |
(3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid |
3a,7a,12a-Trihydroxy-5b-cholan-24-oic Acid |
5β-Cholanic acid, 3α,7α,12α-trihydroxy- (7CI) |
CHOLATE |
Kolbam |
UNII-G1JO7801AE |
Orphacol |
Cholic acid, 5β- |
(3a,5b,7a,12a)-3,7,12-Trihydroxycholan-24-oic acid |
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)- |
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3-α,5-β,7-α,12-α)- |
(3α,5β,7α,8ξ,12α,20R)-3,7,12-Trihydroxycholan-24-oic acid |