Sennoside A

Modify Date: 2024-01-02 18:01:14

Sennoside A structure	Common Name	Sennoside A
	CAS Number	81-27-6	Molecular Weight	862.739
	Density	1.7±0.1 g/cm3	Boiling Point	1144.8±65.0 °C at 760 mmHg
	Molecular Formula	C₄₂H₃₈O₂₀	Melting Point	200-240ºC
	MSDS	Chinese USA	Flash Point	348.6±27.8 °C

Use of Sennoside A

Sennoside A is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication[2].

Name	sennoside A
Synonym	More Synonyms

Description	Sennoside A is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication[2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
References	[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [2]. Esposito F, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391.

Description

Sennoside A is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication[2].

Related Catalog

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

References

[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422.

[2]. Esposito F, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391.

Density	1.7±0.1 g/cm3
Boiling Point	1144.8±65.0 °C at 760 mmHg
Melting Point	200-240ºC
Molecular Formula	C₄₂H₃₈O₂₀
Molecular Weight	862.739
Flash Point	348.6±27.8 °C
Exact Mass	862.195618
PSA	347.96000
LogP	1.88
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.763

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	22-45
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 0
DownStream 2
CAS#:517-44-2 Sennidin B CAS#:82334-26-7 sennidin A-8-mo...

The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.

Biol. Pharm. Bull. 35(12) , 2204-8, (2012)

Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinant...

The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.

Biol. Pharm. Bull. 34(9) , 1438-42, (2011)

Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influe...

Effects of optimized-SopungSunkiwon on memory impairment and enhancement.

Neurosci. Lett. 491(2) , 93-8, (2011)

Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investiga...

Tomato juice

SennosideA

PURSENNID

Sennoside A

Sennoside B

EINECS 201-339-9

MFCD00151527

Glysennid

GLYSENNIDE

SENNOSIDA

PURSENNIDE

SENNOSIDE

[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-

(9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid

(9R,9'S)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid