Sennidin B

Modify Date: 2024-01-02 18:00:37

Sennidin B Structure
Sennidin B structure
Common Name Sennidin B
CAS Number 517-44-2 Molecular Weight 538.458
Density 1.7±0.1 g/cm3 Boiling Point 801.8±65.0 °C at 760 mmHg
Molecular Formula C30H18O10 Melting Point N/A
MSDS N/A Flash Point 452.6±30.8 °C

 Use of Sennidin B


Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation [1][2].

 Names

Name sennidine b
Synonym More Synonyms

 Sennidin B Biological Activity

Description Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation [1][2].
Related Catalog
References

[1]. Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16(8):18439-53.

[2]. Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 801.8±65.0 °C at 760 mmHg
Molecular Formula C30H18O10
Molecular Weight 538.458
Flash Point 452.6±30.8 °C
Exact Mass 538.090027
PSA 189.66000
LogP 8.24
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.806

 Safety Information

Hazard Codes Xi
Risk Phrases 22
Safety Phrases 22-45

 Synthetic Route

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Sennidin B Structure

Sennidin B

CAS#:517-44-2

Sennidin B Structure

Sennidin B

CAS#:517-44-2

Literature: Hattori; Kim; Motoike; Kobashi; Namba Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1338 - 1346

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Sennidin B Structure

Sennidin B

CAS#:517-44-2

Detail
Literature: Hattori; Kim; Motoike; Kobashi; Namba Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1338 - 1346

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Sennidin B Structure

Sennidin B

CAS#:517-44-2

Sennidin B Structure

Sennidin B

CAS#:517-44-2

Literature: Hattori; Kim; Motoike; Kobashi; Namba Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1338 - 1346

 Synonyms

(9R,9'S)-4,4',5,5'-Tetrahydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
1,4-Dichlorobutane-2,3-acetonide
meso-4,5-Bis-chlormethyl-2,2-dimethyl-dioxolan
Sennidin B
[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo-, (9R,9'S)-
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