Ketoleucine

Modify Date: 2024-01-03 19:08:22

Ketoleucine Structure
Ketoleucine structure
Common Name Ketoleucine
CAS Number 816-66-0 Molecular Weight 130.142
Density 1.1±0.1 g/cm3 Boiling Point 190.5±9.0 °C at 760 mmHg
Molecular Formula C6H10O3 Melting Point 8-10 °C
MSDS Chinese USA Flash Point 83.3±15.2 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of Ketoleucine


4-Methyl-2-oxopentanoic acid, an abnormal metabolite, is both a neurotoxin and a metabotoxin.

 Names

Name 4-methyl-2-oxopentanoic acid
Synonym More Synonyms

 Ketoleucine Biological Activity

Description 4-Methyl-2-oxopentanoic acid, an abnormal metabolite, is both a neurotoxin and a metabotoxin.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Yudkoff M, et al. Brain amino acid requirements and toxicity: the example of leucine. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 190.5±9.0 °C at 760 mmHg
Melting Point 8-10 °C
Molecular Formula C6H10O3
Molecular Weight 130.142
Flash Point 83.3±15.2 °C
Exact Mass 130.062988
PSA 54.37000
LogP 0.17
Vapour Pressure 0.2±0.8 mmHg at 25°C
Index of Refraction 1.438
Storage condition 2-8°C

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3265 8/PG 3
WGK Germany 3
Packaging Group III
Hazard Class 8
HS Code 2918300090

 Synthetic Route

 Customs

HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles35

More Articles
Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA.

Biochem. Pharmacol. 80(1) , 104-12, (2010)

The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective ...

Production of α-ketoisocaproate via free-whole-cell biotransformation byRhodococcus opacusDSM 43250 withl-leucine as the substrate

Enzyme Microb. Technol. 49(4) , 321-5, (2011)

This work aims to produce α-ketoisocaproate (KIC) from l-leucine via the free-whole-cell biotransformation of Rhodococcus opacus DSM 43250. The effects of temperature, pH, substrate concentration, cel...

 Synonyms

2-Oxo-4-methylvaleric acid
α-ketoisocaproic acid
2-Oxoisocaproic acid
2-KETOISOCAPROIC ACID
EINECS 212-435-5
4-Methyl-2-oxopentanoic acid
Pentanoic acid, 4-methyl-2-oxo-
&α;-ketoisocaproic acid
2-keto-4-Methylvaleric acid
4-Methyl-2-oxovaleric Acid
4-methyl-2-oxo-Valeric acid
Ketoleucine
MFCD00066204
α-keto-isocaproic acid
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