R(+)-SKF-38393A
Modify Date: 2024-01-13 13:18:19
R(+)-SKF-38393A structure
|
Common Name | R(+)-SKF-38393A | ||
|---|---|---|---|---|
| CAS Number | 81702-42-3 | Molecular Weight | 291.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H18ClNO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of R(+)-SKF-38393A(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1]. |
| Name | (5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | (R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C16H18ClNO2 |
|---|---|
| Molecular Weight | 291.77 |
| Exact Mass | 291.10300 |
| PSA | 52.49000 |
| LogP | 3.50620 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36-22 |
| RIDADR | NONH for all modes of transport |
|
Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,... |
|
|
Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.
Bioorg. Med. Chem. 19 , 5420-31, (2011) To assess the effect of conformational mobility on receptor activity, the β-phenyl substituent of dopamine D(1) agonist ligands of the phenylbenzazepine class, (±)-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]... |
|
|
Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine.
Psychopharmacology 107 , 217, (1992) The present study was designed to assess the behavioral similarity of the effects of prototype dopamine receptor-subtype selective agonists and cocaine. Squirrel monkeys (N = 4) were trained with food... |
| MFCD00055189 |