Tiprelestat
Modify Date: 2025-09-10 11:58:52
Tiprelestat structure
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Common Name | Tiprelestat | ||
|---|---|---|---|---|
| CAS Number | 820211-82-3 | Molecular Weight | 5999.09 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C254H416N72O75S10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TiprelestatTiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease[1]. |
| Name | Tiprelestat |
|---|
| Description | Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Tiprelestat (4 and 8 μM) inhibits P. aeruginosa-secreted peptidase[3]. Tiprelestat (10 μg/mL, 1 h) inhibits LPS-induced MCP-1 production in U937 cells[4]. Tiprelestat (10 μg/mL, 1 h) down-regulates LPS-induced AP-1 and NF-κB activation in U937 cells[4]. Western Blot Analysis[4] Cell Line: U937 cells Concentration: 10 μg/mL Incubation Time: 1 h Result: Prevented LPS-induced degradation of IκBα, IκBβ, and IRAK. |
| In Vivo | Tiprelestat (1 mg/kg, intranasal inhalation) suppresses lung elastase activity and apoptosis in MV-O2 mice[2]. Tiprelestat (0.2 mg/kg, s.c. for 2 weeks) attenuates hypoxic pulmonary hypertension in mice[5]. Animal Model: Mice, treated with Mechanical ventilation with O2-rich gas[2] Dosage: 1 mg/kg Administration: Intranasal inhalation Result: Increased the lung abundance of nuclear Klf4 protein. Animal Model: Su/Hx rat model[5] Dosage: 0.2 mg/kg Administration: Subcutaneous injection (s.c.), daily for 2 weeks. Result: Reduced elastase activity and reversed pulmonary hypertension. |
| Molecular Formula | C254H416N72O75S10 |
|---|---|
| Molecular Weight | 5999.09 |
| InChIKey | MDCUNMLZLNGCQA-HWOAGHQOSA-N |
| SMILES | CCC(C)C1NC(=O)CNC(=O)C2CCCN2C(=O)C2CSSCC(C(=O)NC(Cc3ccccc3)C(=O)NC(C(=O)N3CCCC3C(=O)NC(CCC(N)=O)C(=O)O)C(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)CNC(=O)C3CSSCC4NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)CC)NC(=O)C(CC(C)C)NC(=O)C(C(C)CC)NC(=O)C(C(C)CC)NC(=O)C5CCCN5C(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C5CCCN5C(=O)C(CCCCN)NC(=O)C(NC(=O)C(CO)NC(=O)C(NC(=O)C5CCCN5C(=O)CNC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(CCC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(C)N)C(C)C)C(C)C)C(C)O)CSSCC(NC(=O)C(CSSCC(NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(N)=O)NC(=O)C5CCCN5C(=O)C5CCCN5C(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(C)NC4=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)N2)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC1=O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CO)C(=O)N3 |