Loteprednol etabonate

Modify Date: 2024-01-02 19:28:32

Loteprednol etabonate structure	Common Name	Loteprednol etabonate
	CAS Number	82034-46-6	Molecular Weight	466.952
	Density	1.3±0.1 g/cm3	Boiling Point	600.1±55.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₁ClO₇	Melting Point	220.5-223.5ºC
	MSDS	Chinese USA	Flash Point	316.7±31.5 °C

Use of Loteprednol etabonate

Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. A pronounced binding of the drug to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 were determined in vitro.

Name	loteprednol etabonate
Synonym	More Synonyms

Description	Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. A pronounced binding of the drug to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 were determined in vitro.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Natural Products >> Others
References	[1]. Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10(4):329-39. [2]. Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20. [3]. Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar;55(3):178-83. [4]. Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92(4):455-9. [5]. Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012;2012:789623. [6]. Loteprednol

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

Research Areas >> Inflammation/Immunology

Natural Products >> Others

References

[1]. Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10(4):329-39.

[2]. Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20.

[3]. Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar;55(3):178-83.

[4]. Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92(4):455-9.

[5]. Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012;2012:789623.

[6]. Loteprednol

Density	1.3±0.1 g/cm3
Boiling Point	600.1±55.0 °C at 760 mmHg
Melting Point	220.5-223.5ºC
Molecular Formula	C₂₄H₃₁ClO₇
Molecular Weight	466.952
Flash Point	316.7±31.5 °C
Exact Mass	466.175842
PSA	99.13000
LogP	3.17
Appearance of Characters	white to beige
Vapour Pressure	0.0±3.9 mmHg at 25°C
Index of Refraction	1.571
Storage condition	-20°C Freezer
Water Solubility	DMSO: soluble5mg/mL, clear (warmed)

Loteprednol etabonate MSDS(Chinese)

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2937229000

HS Code	2937229000

Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation.

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Optom. Vis. Sci. 92(1) , 123-31, (2015)

To analyze the safety, efficacy, stability, and predictability of small-incision lenticule extraction to correct myopia.Patients were evaluated preoperatively and then at 1 day, at 2 weeks, and at 1, ...

Loteprednol etabonate 0.5% versus prednisolone acetate 1.0% for the treatment of inflammation after cataract surgery.

J. Cataract Refract. Surg. 39(2) , 168-73, (2013)

To evaluate the efficacy of loteprednol etabonate 0.5% versus prednisolone acetate 1.0% for the control of postoperative inflammation in patients having routine cataract surgery.Private practice, Stil...

Androsta-1,4-diene-17-carboxylic acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-

chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate

(8S,9S,10R,11S,13S,14S,17R)-17-[(éthoxycarbonyl)oxy]-11-hydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrène-17-carboxylate de chlorométhyle

Chloromethyl 17a-ethoxycarbonyloxy-11b-hydroxyandrosta-1,4-diene-3-one-17b-carboxylate

(11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Chloromethyl Ester

Loteprednol (INN)

Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-

Loteprednolum

Loteprednol Etabonate

17a-Ethoxycarbonyloxy-D'-cortienic Acid Chloromethyl Ester

Loteprednol [INN:BAN]

Chloromethyl (11β,17α)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

HGP 1

loteprednol

Chlormethyl-(8S,9S,10R,11S,13S,14S,17R)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-carboxylat

DC Chemicals Limited
China
Product Name: Loteprednol etabonate
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao