PL-017
Modify Date: 2026-08-06 07:43:08
PL-017 structure
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Common Name | PL-017 | ||
|---|---|---|---|---|
| CAS Number | 83397-56-2 | Molecular Weight | 535.635 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 878.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C29H37N5O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 485.1±34.3 °C | |
Use of PL-017PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1]. |
| Name | pl017 |
|---|---|
| Synonym | More Synonyms |
| Description | PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 5.5 nM (125I-FK 33,824 binding to μ site)[1] |
| In Vitro | PL-017 has an IC50 of 10000 nM for 125I-DADLE binding to δ site[1]. |
| In Vivo | PL-017 (0.22, 0.45, 0.9 nmol/rat; i.c.v.) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 878.5±65.0 °C at 760 mmHg |
| Molecular Formula | C29H37N5O5 |
| Molecular Weight | 535.635 |
| Flash Point | 485.1±34.3 °C |
| Exact Mass | 535.279480 |
| PSA | 150.27000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.630 |
| InChIKey | JAKBYSTWCHUQOK-NDBXHCKUSA-N |
| SMILES | CN(C(=O)C1CCCN1C(=O)C(N)Cc1ccc(O)cc1)C(Cc1ccccc1)C(=O)N1CCCC1C(N)=O |
| Storage condition | -20°C |
| Safety Phrases | 22-24/25 |
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