navuridine

Modify Date: 2024-01-04 00:04:04

navuridine structure	Common Name	navuridine
	CAS Number	84472-85-5	Molecular Weight	253.215
	Density	1.357 g/cm	Boiling Point	N/A
	Molecular Formula	C₉H₁₁N₅O₄	Melting Point	161-163ºC
	MSDS	N/A	Flash Point	N/A

Use of navuridine

3′-Azido-2′,3′-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3′-Azido-2′,3′-dideoxyuridine is a potent inhibitor of human immunodeficiency virus (HIV) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC)[1][2][3].

Name	3'-azido-2',3'-dideoxyuridine
Synonym	More Synonyms

Description	3′-Azido-2′,3′-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3′-Azido-2′,3′-dideoxyuridine is a potent inhibitor of human immunodeficiency virus (HIV) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC)[1][2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV
In Vitro	3'-Azido-2',3'-dideoxyuridine 抑制感染 HIV-1 的 PBMC 中的 HIV 复制，中位有效浓度为 0.18-0.46 μM[2]。 3'-Azido-2',3'-dideoxyuridine 抑制人类 T 细胞系 MT-4 和 ATH8 中 HIV 介导的细胞病变效应，中位有效浓度为 0.4 µM[3]。< br/>3'-Azido-2',3'-dideoxyuridine 依次被细胞激酶磷酸化为单磷酸、二磷酸和三磷酸代谢物[3]。
In Vivo	3′-Azido-2′,3′-dideoxyuridine (25-100 mg/kg, 静脉注射或者灌胃，一次)具有良好的药代动力学特征[3]。 Pharmacokinetic Parameters of 3′-Azido-2′,3′-dideoxyuridine in male Sprague-Dawley rats[3]. IV (25 mg/kg) IV (100 mg/kg) PO (25 mg/kg) PO (100 mg/kg) Cmax (μg/mL) 9.2±1.9 41±15 Tmax (h) 0.38±0.13 0.63±0.22 AUC (μg/mL∗h) 19±1.2 156±7.0 12±0.54 70±13 CLT (L/h/kg) 1.4±0.2 0.70±0.09 CLR (L/h/kg) 0.90±0.27 0.43±0.12 t1/2 (h) 0.5±0.0 0.68±0.1 1.0±0.3 1.1±0.4 Vss (L/kg) 0.78±0.26 0.34±0.11 F (%) 60 46 Animal Model: Adult male Sprague-Dawley rats (300-400 g)[3] Dosage: 25, 100 mg/kg Administration: Intravenous bolus injection or oral gavage (Pharmacokinetic Analysis) Result: The oral bioavailability estimates of 3′-Azido-2′,3′-dideoxyuridine at doses of 25 and 100 mg/kg averaged 53%.
References	[1]. Zhu Z, et al. Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs. Mol Pharmacol. 1990 Dec;38(6):929-38. [2]. Chu CK, et al. Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. J Med Chem. 1989 Mar;32(3):612-7. [3]. Kong L, et al. Pharmacokinetic evaluation of 3'-azido-2', 3'-dideoxyuridine-5'-O-valinate-hydrochloride as a prodrug of the anti-HIV nucleoside 3'-azido-2', 3'-dideoxyuridine. Antivir Chem Chemother. 2003 Sep;14(5):263-70.

Density	1.357 g/cm
Melting Point	161-163ºC
Molecular Formula	C₉H₁₁N₅O₄
Molecular Weight	253.215
Exact Mass	253.081100
PSA	134.07000
LogP	-1.12
Storage condition	−20°C

Hazard Codes	Xn
WGK Germany	3
HS Code	2934999090

Precursor 10
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DownStream 8
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