Nylidrin hydrochloride

Modify Date: 2024-01-14 16:30:44

Nylidrin hydrochloride Structure
Nylidrin hydrochloride structure
Common Name Nylidrin hydrochloride
CAS Number 849-55-8 Molecular Weight 335.86800
Density N/A Boiling Point N/A
Molecular Formula C19H26ClNO2 Melting Point 111ºC
MSDS N/A Flash Point N/A

 Use of Nylidrin hydrochloride


Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices.

 Names

Name nylidrin hydrochloride
Synonym More Synonyms

 Nylidrin hydrochloride Biological Activity

Description Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices.
Related Catalog
References

[1]. A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4)

 Chemical & Physical Properties

Melting Point 111ºC
Molecular Formula C19H26ClNO2
Molecular Weight 335.86800
Exact Mass 335.16500
PSA 52.49000
LogP 4.61790
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DO8300000
CHEMICAL NAME :
Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)et hyl)-, hydrochloride
CAS REGISTRY NUMBER :
849-55-8
LAST UPDATED :
199504
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C19-H25-N-O2.Cl-H
MOLECULAR WEIGHT :
335.91
WISWESSER LINE NOTATION :
QR DYQY1&MY1&2R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,538,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3542870
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 24,431,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6178 No. of Facilities: 36 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 357 (estimated) No. of Female Employees: 187 (estimated)

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases 20/21/22
Safety Phrases 36
WGK Germany 3
RTECS DO8300000

 Synonyms

Nylidrin,HCl
Buphedrin
Dilatol
EINECS 212-701-0
MFCD00035085
Arlibide
arlidinhydrochloride
dilatyl
dilatolhydrochloride
Arlidin
bupheninehydrochloride
nylidrine hydrochloride
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