NBI-98782
Modify Date: 2024-01-06 16:39:31
NBI-98782 structure
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Common Name | NBI-98782 | ||
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| CAS Number | 85081-18-1 | Molecular Weight | 319.439 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 457.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H29NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 230.7±28.7 °C | |
Use of NBI-98782NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.IC50 value: 0.97± 0.48 nM [1]Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection. |
| Name | (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol |
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| Synonym | More Synonyms |
| Description | NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.IC50 value: 0.97± 0.48 nM [1]Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 457.8±45.0 °C at 760 mmHg |
| Molecular Formula | C19H29NO3 |
| Molecular Weight | 319.439 |
| Flash Point | 230.7±28.7 °C |
| Exact Mass | 319.214752 |
| PSA | 41.93000 |
| LogP | 3.17 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.562 |
| Storage condition | 2-8℃ |
| (+-)-3c-Isobutyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isochinolin-2t-ol |
| (+)-dihydrotetrabenzaine |
| trans-2 hydroxy-3 isobutyl-9,10 dimethoxy-1,2,3,4,6,7 hexahydro-11bH-benzo(a)quinolizine |
| 2H-Benzo[a]quinolizin-2-ol,1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-,(2R,3R,11bR) |
| (–)-dihydrotetrabenazine |
| (+-)-3c-isobutyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2t-ol |
| (2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol |
| [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol |
| WEQLWGNDNRARGE-DJIMGWMZSA |
| NBI-98782 |