Lithium chloride monohydrate

Modify Date: 2025-08-20 14:48:23

Lithium chloride monohydrate structure	Common Name	Lithium chloride monohydrate
	CAS Number	85144-11-2	Molecular Weight	60.40930
	Density	1.21 g/mL at 20 °C	Boiling Point	1382 °C
	Molecular Formula	ClH₂LiO	Melting Point	605 °C(lit.)
	MSDS	Chinese USA	Flash Point	-4 °F
	Symbol	GHS07	Signal Word	Warning

Use of Lithium chloride monohydrate

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3].

Name	lithium chloride hydrate
Synonym	More Synonyms

Description	Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β
In Vitro	Lithium chloride hydrate (5 和 20 mM，36 小时) 抑制 IBV Beaudette 感染的 BHK 细胞中的细胞病变和 IBV 复制[1]。 Lithium chloride hydrate (5 和 20 mM，36 小时) 抑制 IBV 诱导的 BHK 细胞凋亡和炎症[1]。 Lithium chloride hydrate (1 mg/mL) 提高诱导多能干细胞衍生神经球的效率[4]。 Lithium chloride hydrate (1.2 mM，72 小时) 保护 PC12 细胞免受 Morphine (HY-P1701) 诱导的细胞凋亡[5]。 RT-PCR[1] Cell Line: BHK cells Concentration: 5 and 20 mM Incubation Time: 36 h Result: Blocked the expression of NF-κB, NLRP3, TNF-α, and IL-1β. Blocked levels of Caspase-3, Bax and increased Bcl-2 level.
In Vivo	Lithium chloride hydrate (60 mg/kg，i.p.，每天两次) 改善 Sevoflurane (SEV) 诱导的大鼠记忆障碍[2]。 Lithium chloride hydrate (150 mg/kg，口服，每隔一天) 刺激大鼠拔牙窝修复中的骨形成[6]。 Animal Model: Rats[5] Dosage: 150 mg/kg Administration: Oral administration (p.o.), every other day Result: Produced greater proportion of newly formed bone (NB). Lowered the rate of TRAP-stained cells. Animal Model: Sevoflurane-induced memory impairment rats[2] Dosage: 60 mg/kg Administration: Intraperitoneal injection (i.p.), twice a day. Result: Reduced escape latency, increased time in the objective quadrant and raised platform crossings. Suppresses SEV-induced oxidative stress reduces and reduced SEV-induced apoptosis in the hippocampus.
References	[1]. Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. [2]. Wang, et al. Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10(2):251-258. [3]. Wang Z, et alL. Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. Biol Pharm Bull. 2022 May 1;45(5):605-613. [4]. Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396(8):923-8. [5]. Sahebgharani M, et al. Lithium chloride protects PC12 pheochromocytoma cell line from morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11(6):639-48.

Density	1.21 g/mL at 20 °C
Boiling Point	1382 °C
Melting Point	605 °C(lit.)
Molecular Formula	ClH₂LiO
Molecular Weight	60.40930
Flash Point	-4 °F
Exact Mass	59.99540
PSA	9.23000
Appearance of Characters	beads
Index of Refraction	n20/D 1.381
Storage condition	2-8°C
Water Solubility	H2O: soluble

Lithium chloride monohydrate MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	F,Xn
Risk Phrases	11-36/37/38-22
Safety Phrases	S16-S26
RIDADR	UN 2789 8/PG 2
WGK Germany	1
RTECS	OJ5950000

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