BAPTA

Modify Date: 2024-01-07 12:41:52

BAPTA Structure
BAPTA structure
 Common Name BAPTA
CAS Number 85233-19-8 Molecular Weight 476.433
Density 1.5±0.1 g/cm3 Boiling Point 766.6±60.0 °C at 760 mmHg
Molecular Formula C22H24N2O10 Melting Point 177-179 °C
MSDS USA Flash Point 417.4±32.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of BAPTA


BAPTA is a specific chelator of Ca2+, suppresses intracellular reactive oxygen species (ROS) levels.

 Names

Name bapta
Synonym More Synonyms

 BAPTA Biological Activity

Description BAPTA is a specific chelator of Ca2+, suppresses intracellular reactive oxygen species (ROS) levels.
Related Catalog
Target

Ca2+ chelator[1]

In Vitro Regarding ROS generation, a Ca2+ specific chelator, BAPTA, suppresses ROS generation of Sodium lauryl sulfate (SLS)-exposed HaCaT keratinocytes[1]. Depolarization does not increase the resting open probability of the mechanoelectrical transducer (MET) current of Tmc1Bth/Bth OHCs, whereas raising the intracellular concentration of the Ca2+ chelator BAPTA causes smaller increases in resting open probability in Bthmutant outer hair cells (OHCs) than in wild-type control cells. In the presence of 0.1 mM BAPTA, nonsaturating bundle displacements causes the MET current to adapt in both genotypes, exactly as seen when 1 mM EGTA is used in the intracellular solution. In the presence of 10 mM intracellular BAPTA, the time-dependent MET current decline is abolished and the resting Popen increased to near 50% of the maximal MET current in OHCs from both Tmc1+/+ and Tmc1Bth/Bth mice. The relation between the MET current and bundle displacement shows that increasing the intracellular BAPTA concentration from 0.1 to 10 mM significantly increased (p<0.0001) the resting Popen of the MET current in both Tmc1+/+ (0.1 mM, 8±1.6%, n=4; 10 mM, 39.6±2.7%, n=5) and Tmc1Bth/Bth (0.1 mM, 10.4±2.2%, n=3; 10 mM, 46.5±9.9%, n=6). No significant differences are seen between the two genotypes for both BAPTA concentrations. However, 3 and 5 mM BAPTA are less effective in shifting the MET current-bundle displacement curves in Tmc1Bth/Bth than in Tmc1+/+ OHCs. In Tmc1+/+, increasing the BAPTA concentration from 0.1 mM to either 3 or 5 mM produces a highly significant increase in Popen (post hoc test from one-way ANOVA, p<0.01 and p<0.001, respectively); in Tmc1Bth/Bth, the same comparison produced no or a much reduced increase in Popen (n.s. and p<0.05, respectively)[2].
References

[1]. Mizutani T, et al. Sodium Lauryl Sulfate Stimulates the Generation of Reactive Oxygen Species through Interactions with Cell Membranes. J Oleo Sci. 2016 Dec 1;65(12):993-1001.

[2]. Corns LF, et al. Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells. J Neurosci. 2016 Jan 13;36(2):336-49.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 766.6±60.0 °C at 760 mmHg
Melting Point 177-179 °C
Molecular Formula C22H24N2O10
Molecular Weight 476.433
Flash Point 417.4±32.9 °C
Exact Mass 476.143097
PSA 174.14000
LogP 0.13
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.657
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

1,2-Bis(2-Nitrophenoxy)ethane structure

1,2-Bis(2-Nitro...

CAS#:51661-19-9

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BAPTA Structure

BAPTA

CAS#:85233-19-8

Literature: Bulletin des Societes Chimiques Belges, , vol. 103, # 7-8 p. 309 - 320
Sodium 2-nitrophenoxide structure

Sodium 2-nitrop...

CAS#:824-39-5

~%

BAPTA Structure

BAPTA

CAS#:85233-19-8

Literature: Bulletin des Societes Chimiques Belges, , vol. 103, # 7-8 p. 309 - 320
o-Nitrophenol structure

o-Nitrophenol

CAS#:88-75-5

~%

BAPTA Structure

BAPTA

CAS#:85233-19-8

Literature: Bulletin des Societes Chimiques Belges, , vol. 103, # 7-8 p. 309 - 320
2,2'-[1,2-Ethanediylbis(oxy)]dianiline structure

2,2'-[1,2-Ethan...

CAS#:52411-34-4

~%

BAPTA Structure

BAPTA

CAS#:85233-19-8

Literature: Bulletin des Societes Chimiques Belges, , vol. 103, # 7-8 p. 309 - 320
BAPTA tetraethyl ester structure

BAPTA tetraethy...

CAS#:73630-07-6

~%

BAPTA Structure

BAPTA

CAS#:85233-19-8

Literature: Bulletin des Societes Chimiques Belges, , vol. 103, # 7-8 p. 309 - 320

 Articles116

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 Synonyms

2,2',2'',2'''-[ethane-1,2-diylbis(oxybenzene-2,1-diylnitrilo)]tetraacetic acid
N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine]
1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
MFCD00036255
Bapeta
2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid
1,2-bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic acid
5F-Bapta
2,2',2'',2'''-[1,2-Ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetic acid
2,2',2'',2'''-[Ethane-1,2-diylbis(oxy-2,1-phenylenenitrilo)]tetraacetic acid
1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
BAPTA
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352000-08-9
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5,5'-Fbapta
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dibromobapta
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Chemsrc provides BAPTA(CAS#:85233-19-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BAPTA are included as well.>> amp version: BAPTA

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