Choline Fenofibrate

Modify Date: 2025-08-24 18:15:32

Choline Fenofibrate Structure
Choline Fenofibrate structure
Common Name Choline Fenofibrate
CAS Number 856676-23-8 Molecular Weight 421.91400
Density N/A Boiling Point 486.5ºC at 760 mmHg
Molecular Formula C22H28ClNO5 Melting Point N/A
MSDS N/A Flash Point 248ºC

 Use of Choline Fenofibrate


Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. IC50 value:Target:Several clinical trials have been developed with Choline Fenofibrate on Reverse Cholesterol Transport, Macular Edema and Hypertriglyceridemia.

 Names

Name 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate,2-hydroxyethyl(trimethyl)azanium
Synonym More Synonyms

 Choline Fenofibrate Biological Activity

Description Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. IC50 value:Target:Several clinical trials have been developed with Choline Fenofibrate on Reverse Cholesterol Transport, Macular Edema and Hypertriglyceridemia.
Related Catalog
References

[1]. Jones PH, Bays HE, Davidson MH et al. Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme. Clin Drug Investig. 2008;28(10):625-34.

[2]. Mohiuddin SM, Pepine CJ, Kelly MT et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study. Am Heart J. 2009 Jan;157(1):195-203.

[3]. Zhu T, Awni WM, Hosmane B et al. ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans. J Clin Pharmacol. 2009 Jan;49(1):63-71.

[4]. Goldberg AC, Bays HE, Ballantyne CM et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia. Am J Cardiol. 2009 Feb 15;103(4):515-22.

[5]. Campbell J, Mohiuddin SM. The role of a new formulation of fenofibric acid in the treatment of mixed dyslipidemia in type 2 diabetes. Drugs Today (Barc). 2010 Oct;46(10):757-64.

 Chemical & Physical Properties

Boiling Point 486.5ºC at 760 mmHg
Molecular Formula C22H28ClNO5
Molecular Weight 421.91400
Flash Point 248ºC
Exact Mass 421.16600
PSA 86.66000
LogP 2.16320
Storage condition 2-8℃

 Synthetic Route

~70%

Choline Fenofibrate Structure

Choline Fenofibrate

CAS#:856676-23-8

Literature: US2008/275270 A1, ; Page/Page column 3 ;

~75%

Choline Fenofibrate Structure

Choline Fenofibrate

CAS#:856676-23-8

Literature: WO2010/86700 A2, ; Page/Page column 7 ;

~68%

Choline Fenofibrate Structure

Choline Fenofibrate

CAS#:856676-23-8

Literature: US2008/275270 A1, ; Page/Page column 3 ;

 Synonyms

Choline fenofibrate
UNII-4BMH7IZT98
fenofibric acid choline salt
ABT-335
Fenofibrate de choline
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