Choline Hydroxide

Modify Date: 2024-01-02 11:42:09

Choline Hydroxide Structure
Choline Hydroxide structure
Common Name Choline Hydroxide
CAS Number 123-41-1 Molecular Weight 121.178
Density 1.09 g/mL at 20 °C Boiling Point N/A
Molecular Formula C5H15NO2 Melting Point N/A
MSDS N/A Flash Point 92 °F

 Use of Choline Hydroxide


Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism [1][2][3].

 Names

Name 2-Hydroxyethyltrimethylammonium Hydroxide
Synonym More Synonyms

 Choline Hydroxide Biological Activity

Description Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism [1][2][3].
Related Catalog
In Vitro Choline hydroxide can be used as the standard alkaline, and (0.5 M) results pHo shifts rapidly to 7.59 in a sucrose medium (pH at 7.08)[1]. Choline hydroxide (0.1-0.5 g/mL), together with organic carboxylic acids, makes preparation of ionic liquids, which is used for prepare a ionic liquid-reverse micelle drug-carrying delivery system and involves in epidermal desensitization research[2].
References

[1]. Mitchell P, et al. Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria. Eur J Biochem. 1969 Feb;7(4):471-84.

[2]. Ding Y, et al. An ionic liquid-reverse micelle drug delivery system for epidermal desensitization therapy and its preparation method and application: China, CN113975224. 2022-01-28.

[3]. Wang F, et al. Short communication: Effects of dietary deoiled soy lecithin supplementation on circulating choline and choline metabolites, and the plasma phospholipid profile in Holstein cows fed palm fat. J Dairy Sci. 2021 Feb;104(2):1838-1845.

 Chemical & Physical Properties

Density 1.09 g/mL at 20 °C
Molecular Formula C5H15NO2
Molecular Weight 121.178
Flash Point 92 °F
Exact Mass 121.110275
PSA 43.29000
Index of Refraction n20/D 1.4304
Storage condition 2-8°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility miscible

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GA4025500
CHEMICAL NAME :
Choline hydroxide
CAS REGISTRY NUMBER :
123-41-1
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C5-H14-N-O.H-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21400 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1357,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1710 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 11518 (estimated) No. of Female Employees: 5852 (estimated)

 Safety Information

Hazard Codes C:Corrosive;
Risk Phrases R35
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3286 3/PG 2
WGK Germany 1
RTECS GA4025500
Packaging Group II
Hazard Class 8
HS Code 2923900090

 Synthetic Route

 Customs

HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1)
Bursine
Gossypine
Sincaline
VIDINE
MFCD00002831
EINECS 204-625-1
2-Hydroxy-N,N,N-trimethylethanaminium hydroxide
Luridine
Fagine
Choline hydroxide
UNII:7THJ3EG9SY
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