CU-3

Modify Date: 2024-01-05 02:29:15

CU-3 structure	Common Name	CU-3
	CAS Number	861123-84-4	Molecular Weight	392.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₂N₂O₄S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CU-3

CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

Name	CU-3

Description	CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
References	[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.

Molecular Formula	C₁₆H₁₂N₂O₄S₃
Molecular Weight	392.47

CU-3

Use of CU-3

Names

CU-3 Biological Activity

Chemical & Physical Properties