CMPD101

Modify Date: 2025-08-20 17:55:32

CMPD101 structure	Common Name	CMPD101
	CAS Number	865608-11-3	Molecular Weight	466.458
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₁F₃N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CMPD101

CMPD101, is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM. CMPD101 also inhibits ROCK-2 and PKCα (IC50s=1.4 μM and 8.1 μM, respectively)[1].

Name	3-({[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide
Synonym	More Synonyms

Description	CMPD101, is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM. CMPD101 also inhibits ROCK-2 and PKCα (IC50s=1.4 μM and 8.1 μM, respectively)[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	GRK2:18 nM (IC50) GRK3:5.4 nM (IC50) PKCα:8.1 μM (IC50) ROCK2:1.4 μM (IC50)
References	[1]. Okawa T, et al. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J Med Chem. 2017 Aug 24;60(16):6942-6990.

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₄H₂₁F₃N₆O
Molecular Weight	466.458
Exact Mass	466.172882
LogP	3.30
Index of Refraction	1.622

3-({[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide

Benzamide, 3-[[[4-methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]-

CMPD101

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CMPD101
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Takeda compound 101
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Takeda compound 101
Price: $500.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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CMPD101

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.