Ladarixin sodium
Modify Date: 2024-01-06 17:38:12
Ladarixin sodium structure
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Common Name | Ladarixin sodium | ||
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| CAS Number | 865625-56-5 | Molecular Weight | 397.323 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H11F3NNaO6S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ladarixin sodiumA novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM; prevents PMN infiltration and tissue damage in several models of IR injury in vivo; abrogates motility and induces apoptosis in cultured cutaneous and uveal melanoma cells and xenografts; also prevents inflammation-mediated damage in MLD-STZ, prevents and reverses diabetes in NOD mice. Diabetes Phase 2 Clinical |
| Name | Sodium (1Z,2R)-N-(methylsulfonyl)-2-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanimidate |
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| Synonym | More Synonyms |
| Description | A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM; prevents PMN infiltration and tissue damage in several models of IR injury in vivo; abrogates motility and induces apoptosis in cultured cutaneous and uveal melanoma cells and xenografts; also prevents inflammation-mediated damage in MLD-STZ, prevents and reverses diabetes in NOD mice. Diabetes Phase 2 Clinical |
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| References | References 1. Garau A, et al. Eur Cytokine Netw. 2006 Mar;17(1):35-41. 2. Citro A, et al. Diabetes. 2015 Apr;64(4):1329-40. 3. Kemp DM, et al. Oncotarget. 2017 Feb 28;8(9):14428-14442. 4. Bertini R, et al. Br J Pharmacol. 2012 Jan;165(2):436-54. View Related Products by Target Chemokine Receptor (CCR and CXCR) Diabetes |
| Molecular Formula | C11H11F3NNaO6S2 |
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| Molecular Weight | 397.323 |
| Exact Mass | 396.987762 |
| Methanesulfonic acid, 1,1,1-trifluoro-, 4-[(1R)-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl]phenyl ester, sodium salt (1:1) |
| Sodium (1Z,2R)-N-(methylsulfonyl)-2-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanimidate |