Penicillin-V

Modify Date: 2024-01-03 15:54:21

Penicillin-V structure	Common Name	Penicillin-V
	CAS Number	87-08-1	Molecular Weight	350.389
	Density	1.5±0.1 g/cm3	Boiling Point	681.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₈N₂O₅S	Melting Point	120 - 128ºC
	MSDS	N/A	Flash Point	365.9±31.5 °C

Use of Penicillin-V

Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].

Name	phenoxymethylpenicillin
Synonym	More Synonyms

Description	Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L[2]. Penicillin V (0.002-8.0 mg/L) shows antibacterial activity for Clostridium difficile with an MIC50 value of 4.0 mg/L and an MIC90 value of 8.0 mg/L[3]. Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with an MIC value of 0.016 mg/L[4].
In Vivo	Penicillin V (0.063-0.25 mg/kg; s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle[4]. Penicillin V (2 mg/kg; s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L·h)[4]. Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats[5]. Animal Model: Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus[4] Dosage: 0.063, 0.13, 0.25 mg/kg Administration: S.c. Result: Decreased the number of CFU (1.34×107 counts/mL) compared to controls (3.5×107 counts/mL) at the dose of 0.25 mg/kg.
References	[1]. Sabath LD. Et, al. Phenoxymethylpenicillin (penicillin V) and phenethicillin. Med Clin North Am. 1970 Sep;54(5):1101-11. [2]. Kamme C, et, al. In vitro effect on group A streptococci of loracarbef versus cefadroxil, cefaclor and penicillin V. Scand J Infect Dis. 1993;25(1):37-42. [3]. Norén T, et, al. In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993-2007 in Sweden. Clin Microbiol Infect. 2010 Aug;16(8):1104-10. [4]. Overbosch D, et, al. Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin. Br J Clin Pharmacol. 1985 May;19(5):657-68. [5]. Hermansson A, et, al. Prevention of experimental acute otitis media with penicillin V. Acta Otolaryngol. Jan-Feb 1990;109(1-2):119-23. [6]. Timm A, et al. Photolysis of four β‑lactam antibiotics under simulated environmental conditions: Degradation, transformation products and antibacterial activity. Sci Total Environ. 2019 Feb 15;651(Pt 1):1605-1612.

Density	1.5±0.1 g/cm3
Boiling Point	681.4±55.0 °C at 760 mmHg
Melting Point	120 - 128ºC
Molecular Formula	C₁₆H₁₈N₂O₅S
Molecular Weight	350.389
Flash Point	365.9±31.5 °C
Exact Mass	350.093628
PSA	121.24000
LogP	1.88
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.651
Storage condition	−20°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	Very slightly soluble in water, soluble in ethanol (96 per cent).

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RY4025000

CHEMICAL NAME :: Penicillanic acid, 6-phenoxyacetamido-

CAS REGISTRY NUMBER :: 87-08-1

BEILSTEIN REFERENCE NO. :: 0096259

LAST UPDATED :: 199612

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C16-H18-N2-O5-S

MOLECULAR WEIGHT :: 350.42

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMV1OR& F1 F1 GVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 10 mg/kg/2D

TOXIC EFFECTS :: Liver - liver function tests impaired Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2220 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1775 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6578 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1351 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1775 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 822 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1096 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 200 ug/L

REFERENCE :: NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 22,105,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83957 No. of Facilities: 61 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2874 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83957 No. of Facilities: 114 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1964 (estimated) No. of Female Employees: 959 (estimated)

Hazard Codes	Xn
Risk Phrases	R42/43
Safety Phrases	22-36
RIDADR	NONH for all modes of transport
RTECS	RY4025000
HS Code	3003101300

Precursor 8
CAS#:551-16-6 6-Aminopenicill... CAS#:701-99-5 Phenoxyacetyl c... CAS#:65538-78-5 2-bromoethyl (2... CAS#:52-67-5 D-penicillamine
CAS#:1030-50-8 (4S)-2t-((R)-am... CAS#:1057-37-0 (4S)-2t-[(R)-te... CAS#:1056-69-5 (4S)-2t-((R)-te... CAS#:59168-65-9 2-[(1,3-dioxois...
DownStream 3
CAS#:551-16-6 6-Aminopenicill... CAS#:122-59-8 Phenoxyacetic acid CAS#:2315-05-1 methyl 3,3-dime...

HS Code	3003101300

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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: phenoxymethylpenicillin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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