6-Aminopenicillanic acid
Modify Date: 2026-07-02 17:14:10
6-Aminopenicillanic acid structure
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Common Name | 6-Aminopenicillanic acid | ||
|---|---|---|---|---|
| CAS Number | 551-16-6 | Molecular Weight | 216.258 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 460.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C8H12N2O3S | Melting Point | 198-200 °C (dec.)(lit.) | |
| MSDS | USA | Flash Point | 232.1±28.7 °C | |
Use of 6-Aminopenicillanic acid6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA)[1]. |
| Name | 6-aminopenicillanic acid |
|---|---|
| Synonym | More Synonyms |
| Description | 6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA)[1]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 460.2±45.0 °C at 760 mmHg |
| Melting Point | 198-200 °C (dec.)(lit.) |
| Molecular Formula | C8H12N2O3S |
| Molecular Weight | 216.258 |
| Flash Point | 232.1±28.7 °C |
| Exact Mass | 216.056870 |
| PSA | 108.93000 |
| LogP | -0.36 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.656 |
| InChIKey | NGHVIOIJCVXTGV-ALEPSDHESA-N |
| SMILES | CC1(C)SC2C(N)C(=O)N2C1C(=O)O |
| Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
|---|---|
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R42/43 |
| Safety Phrases | S22-S36/37-S45-S37-S24 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XH8225000 |
| HS Code | 2941109300 |
| Precursor 5 | |
|---|---|
| DownStream 10 | |
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CAS#:61-33-6| HS Code | 2941109300 |
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| Summary | 2941109300. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:Q(report of inspection of soundness on import medicines). MFN tariff:4.0%. General tariff:20.0% |
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Enhanced production of 6-aminopenicillanic acid in aqueous methyl isobutyl ketone system with immobilized penicillin G acylase.
Prep Biochem Biotechnol. 40(1) , 38-45, (2010) Enzymatic hydrolysis of penicillin G for production of 6-amino-penicillanic-acid (6-APA) was achieved by using penicillin G acylase as catalyst in an aqueous-methylisobutyl ketone (MIBK) system. The o... |
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Monitoring bioreactors using principal component analysis: production of penicillin G acylase as a case study.
Bioprocess Biosyst. Eng. 33(5) , 557-64, (2010) The complexity of biological processes often makes impractical the development of detailed, structured phenomenological models of the cultivation of microorganisms in bioreactors. In this context, dat... |
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Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase.
Bioorg. Med. Chem. Lett. 19(14) , 3787-90, (2009) We report the first synthesis of a 5S penem, known to bind bacterial type I signal peptidase, from the commercially available and inexpensive 6-aminopenicillanic acid. We report the first in vivo acti... |
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa...
Source: 824
Target: AR protein [Homo sapiens]
External Id: MDAN535
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Name: pKa (acid-base dissociation constant) as determined by Liao ref: J Chem Info Model 20...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449006
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
|
|
Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign...
Source: 824
Target: N/A
External Id: MDAV150
|
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Name: qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel...
Source: 824
Target: RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein
External Id: ELG271
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Name: TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells
Source: ChEMBL
Target: Solute carrier family 15 member 2
External Id: CHEMBL2076201
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Name: TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells
Source: ChEMBL
Target: Solute carrier family 15 member 1
External Id: CHEMBL2076202
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Name: qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal...
Source: 824
Target: thyroid hormone receptor beta isoform 2 [Rattus norvegicus]
External Id: TRN186
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| [2S-(2a,5a,6b)]-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| EINECS 208-993-4 |
| 6-aps |
| 6-AMINO PENICILLINIC ACID |
| 6-Aminopenicillanic acid |
| penicin |
| 6-Aminopenicillansure |
| aminopenicillanicacid |
| MFCD00005176 |
| 6-APA |
| 6b-Aminopenicillanic Acid |
| (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin Impurity 1 |