5-Bromoisatin

Modify Date: 2024-01-02 09:43:04

5-Bromoisatin Structure
5-Bromoisatin structure
 Common Name 5-Bromoisatin
CAS Number 87-48-9 Molecular Weight 226.027
Density 1.8±0.1 g/cm3 Boiling Point 136ºC
Molecular Formula C8H4BrNO2 Melting Point 247-252 °C(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Names

Name 5-bromo-1H-indole-2,3-dione
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 136ºC
Melting Point 247-252 °C(lit.)
Molecular Formula C8H4BrNO2
Molecular Weight 226.027
Exact Mass 224.942535
PSA 46.17000
LogP 1.33
Index of Refraction 1.650

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7875000
CHEMICAL NAME :
Indole-2,3-dione, 5-bromo-
CAS REGISTRY NUMBER :
87-48-9
BEILSTEIN REFERENCE NO. :
0383760
LAST UPDATED :
199709
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C8-H4-Br-N-O2
MOLECULAR WEIGHT :
226.04
WISWESSER LINE NOTATION :
T56 BMVVJ GE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,821,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),93,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3430 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),93,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
437 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,858,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45 gm/kg/30D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),93,1988

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R37/38;R41
Safety Phrases S26-S36/39-S37/39
RIDADR 2811
WGK Germany 2
RTECS NL7875000
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles19

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Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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 Synonyms

5-monobromoisatin
MFCD00005719
INDOLE-2,3-DIONE,5-BROMO
5-bromo-1,3-dihydro-indol-2-one
5-Bromoindole-2,3-dione
5-Bromisatin [Czech]
1H-Indole-2,3-dione, 5-bromo-
Isatin,5-bromo
1H-Indole-2,3-dione,5-bromo
5-Bromo-1H-indole-2,3-dione
5-Bromisatin
5-Bromoindoline-2,3-dione
5-bromo-2,3-dihydro-1H-indole-2,3-dione
EINECS 201-747-7
5-Bromoisatin
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5-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
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Chemsrc provides 5-Bromoisatin(CAS#:87-48-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 5-Bromoisatin are included as well.>> amp version: 5-Bromoisatin

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