5-Bromoisatin
5-Bromoisatin structure
|
Common Name | 5-Bromoisatin | ||
|---|---|---|---|---|
| CAS Number | 87-48-9 | Molecular Weight | 226.027 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 136ºC | |
| Molecular Formula | C8H4BrNO2 | Melting Point | 247-252 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
|
Mass spectrometry imaging reveals new biological roles for choline esters and Tyrian purple precursors in muricid molluscs.
Sci. Rep. 5 , 13408, (2015) Despite significant advances in chemical ecology, the biodistribution, temporal changes and ecological function of most marine secondary metabolites remain unknown. One such example is the association between choline esters and Tyrian purple precursors in mur... |
|
|
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
J. Med. Chem. 50 , 1876-85, (2007) Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the metabolism and detoxification of xenobiotics. Numerous clinically used drugs including Demerol, lidocaine, capecitabine, and CPT-11 are hydrolyzed by these enzymes. Hence, the ide... |
|
|
In vitro cytotoxicity evaluation of some substituted isatin derivatives.
Bioorg. Med. Chem. 15 , 931-8, (2007) A range of substituted 1H-indole-2,3-diones (isatins) were synthesized using standard procedures and their cytotoxicity evaluated against the human monocyte-like histiocytic lymphoma (U937) cell line in vitro. SAR studies identified C(5), C(6), and C(7) subst... |
|
|
QSAR study of isatin analogues as in vitro anti-cancer agents.
Eur. J. Med. Chem. 45 , 1113-8, (2010) Quantitative structure activity relationships (QSAR) of anti-cancer isatin derivatives were discovered by multiple linear regressions (MLR) and genetic algorithm partial least squares (GA-PLS) methods. Topological, chemical, geometrical and functional groups ... |
|
|
[Effect of isatin and its derivatives on some indicators of carbohydrate metabolism].
Vopr. Med. Khim. 30(5) , 56-9, (1984) Effect of isatin and of three its derivatives on content of lactate, pyruvate and glycogen was studied in rat tissues. The substances studied, except of 5-butylisatin, decreased the content of lactic acid with simultaneous increase of glycogen content in live... |
|
|
[The positive inotropic activity of 5-bromoisatin (5-bromo-indoline-2,3-dione)].
Eksp. Klin. Farmakol. 62(3) , 20-4, (1999) The inotropic activity of 5-bromisatin (5-bromindolyn-2,3-dion) which possesses antihypoxic properties was studied on rhythmically stimulated papillary muscles of guinea pigs, and the changes in the force of their contractions were recorded. The inotropic eff... |
|
|
Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.
Bioorg. Med. Chem. Lett. 21 , 2692, (2011) Inhibitors of human transglutaminase 2 (TG2) are anticipated to be useful in the therapy of a variety of diseases including celiac sprue as well as certain CNS disorders and cancers. A class of 3-acylidene-2-oxoindoles was identified as potent reversible inhi... |
|
|
SiO2 mediated reaction of isatin with N-halosaccharins: A regiospecific preparation of 5-haloisatins. de Souza SPL, et al.
Heterocycl. Comm. 9(1) , 31-34, (2003)
|
|
|
Possible psychopharmacological agents. X. Synthesis of Some Fluorine Containing Indole-2, 3-dione Derivatives. Joshi KC, et al.
J. Prakt. Chem. 322(2) , 314-320, (1980)
|
|
|
Synthesis of isatin and 5-bromoisatin derivatives. Mesropyan EG, et al.
Russ. J. Org. Chem. 37(10) , 1476-1477, (2001)
|