ZAP 180013
Modify Date: 2024-01-10 08:42:26
ZAP 180013 structure
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Common Name | ZAP 180013 | ||
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| CAS Number | 873080-25-2 | Molecular Weight | 454.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H17Cl2N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZAP 180013ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1]. |
| Name | ZAP-180013 |
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| Description | ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1]. |
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| Related Catalog | |
| Target |
IC50: 1.8 μM (ZAP-70)[1] |
| In Vitro | ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains of the T cell receptor, where ZAP-70 is activated and colocalized with its substrates. Inhibitors of ZAP-70 could potentially function as treatments for autoimmune diseases or organ transplantation. ZAP-180013 disrupts the interaction between ZAP-70 and the T cell antigen receptor. The IC50s in both FP and TR-FRET assays for ZAP-180013 are 9.6 μM and 16.841 μM, respectively[1]. |
| References |
| Molecular Formula | C19H17Cl2N3O4S |
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| Molecular Weight | 454.33 |
| Hazard Codes | Xn |
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