3-Vinyl-2-pyrrolidinone

Modify Date: 2025-08-21 17:40:09

3-Vinyl-2-pyrrolidinone Structure
3-Vinyl-2-pyrrolidinone structure
 Common Name 3-Vinyl-2-pyrrolidinone
CAS Number 88-12-0 Molecular Weight 111.142
Density 1.1±0.1 g/cm3 Boiling Point 249.1±29.0 °C at 760 mmHg
Molecular Formula C6H9NO Melting Point 13-14 °C
MSDS Chinese USA Flash Point 134.7±9.2 °C
Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08		 Signal Word Danger

 Names

Name N-Vinyl-2-Pyrrolidinone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 249.1±29.0 °C at 760 mmHg
Melting Point 13-14 °C
Molecular Formula C6H9NO
Molecular Weight 111.142
Flash Point 134.7±9.2 °C
Exact Mass 111.068413
PSA 20.31000
LogP -0.72
Vapour density 3.8 (vs air)
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.554
InChIKey WHNWPMSKXPGLAX-UHFFFAOYSA-N
SMILES C=CN1CCCC1=O
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility miscible

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY6107000
CHEMICAL NAME :
2-Pyrrolidinone, 1-vinyl-
CAS REGISTRY NUMBER :
88-12-0
BEILSTEIN REFERENCE NO. :
0110513
LAST UPDATED :
199806
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C6-H9-N-O
MOLECULAR WEIGHT :
111.16
WISWESSER LINE NOTATION :
T5NVTJ A1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
BurLW# Personal Communication from L.W. Burnette, Material Safety Dept., GAF Corp., 1361 Alps Rd., Wayne, NJ 07470, Nov. 2, 1978 Volume(issue)/page/year: 02NOV1978 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BurLW# Personal Communication from L.W. Burnette, Material Safety Dept., GAF Corp., 1361 Alps Rd., Wayne, NJ 07470, Nov. 2, 1978 Volume(issue)/page/year: 02NOV1978
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BurLW# Personal Communication from L.W. Burnette, Material Safety Dept., GAF Corp., 1361 Alps Rd., Wayne, NJ 07470, Nov. 2, 1978 Volume(issue)/page/year: 02NOV1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BurLW# Personal Communication from L.W. Burnette, Material Safety Dept., GAF Corp., 1361 Alps Rd., Wayne, NJ 07470, Nov. 2, 1978 Volume(issue)/page/year: 02NOV1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2600 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45 ppm/6H/1W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 ppm/6H/7W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 ppm/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - changes in liver weight Related to Chronic Data - death
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 ppm/6H/1Y-I
TOXIC EFFECTS :
Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 ppm/6H/1W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 ppm/6H/7W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
45 ppm/6H/13W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1061,1997 ** TUMORIGENIC DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,1041,1997 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,461,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,461,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84629 No. of Facilities: 1085 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 4340 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84629 No. of Facilities: 201 (estimated) No. of Industries: 6 No. of Occupations: 11 No. of Employees: 6772 (estimated) No. of Female Employees: 1243 (estimated)

 Safety Information

Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger
Hazard Statements H302 + H312 + H332-H318-H335-H351-H373
Precautionary Statements P260-P280-P301 + P312 + P330-P305 + P351 + P338 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22;R37;R40;R41;R48/20
Safety Phrases S26-S36/37/39
RIDADR UN 2810 6.1/PG 3
WGK Germany 1
RTECS UY6107000
Packaging Group III
Hazard Class 6.1
HS Code 29337900

 Synthetic Route

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

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 Synonyms

MFCD00003197
EINECS 201-800-4
3-Vinyl-2-pyrrolidinone
N-Vinyl-2-pyrrolidone
NVP
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