Myosmine

Modify Date: 2024-01-01 22:34:52

Myosmine structure	Common Name	Myosmine
	CAS Number	532-12-7	Molecular Weight	146.189
	Density	1.1±0.1 g/cm3	Boiling Point	244.7±22.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀N₂	Melting Point	42-44°C
	MSDS	Chinese USA	Flash Point	101.8±22.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Myosmine

Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].

Name	3-(3,4-dihydro-2H-pyrrol-5-yl)pyridine
Synonym	More Synonyms

Description	Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Metabolic Disease
Target	Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1]
In Vitro	Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine[2].
In Vivo	Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine[2].
References	[1]. G Ferretti, er al. Binding of Nicotine and Homoazanicotine Analogues at Neuronal Nicotinic Acetylcholinergic (nACh) Receptors. Bioorg Med Chem Lett. 2003 Feb 24;13(4):733-5. [2]. Wolfgang Zwickenpflug, et al. Metabolism of Myosmine in Wistar Rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56.

Density	1.1±0.1 g/cm3
Boiling Point	244.7±22.0 °C at 760 mmHg
Melting Point	42-44°C
Molecular Formula	C₉H₁₀N₂
Molecular Weight	146.189
Flash Point	101.8±22.3 °C
Exact Mass	146.084396
PSA	25.25000
LogP	-0.63
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.611
Storage condition	2-8°C
Stability	Moisture, Temperature Sensitive

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT7660000

CHEMICAL NAME :: Pyridine, 3-(1-pyrrolin-2-yl)-

CAS REGISTRY NUMBER :: 532-12-7

BEILSTEIN REFERENCE NO. :: 0119254

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-N2

MOLECULAR WEIGHT :: 146.21

WISWESSER LINE NOTATION :: T6NJ C- BT5N AUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1875 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 63,423,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 63,423,1946

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT7660000
HS Code	2933990090

Precursor 8
CAS#:93-60-7 Methyl nicotinate CAS#:36740-10-0 4-oxo-4-pyridin... CAS#:123-75-1 Pyrrolidine CAS#:1120-90-7 3-Iodopyridine
CAS#:22083-74-5 (±)-nicotine CAS#:88-12-0 3-Vinyl-2-pyrro... CAS#:614-18-6 Ethyl nicotinate CAS#:87549-96-0 1-(3-pyridyl)cy...
DownStream 8
CAS#:59578-62-0 4-Hydroxy-1-(Py... CAS#:80508-23-2 rac N'-Nitroson... CAS#:5746-86-1 (±)-Nornicotine CAS#:1772-29-8 4-piperidin-3-y...
CAS#:22083-74-5 (±)-nicotine CAS#:54-11-5 L-Nicotine CAS#:25162-00-9 (+)-Nicotine CAS#:6021-23-4 4-pyridin-3-ylb...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

A reversed-phase HPLC-UV method developed and validated for simultaneous quantification of six alkaloids from Nicotiana spp.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 997 , 142-5, (2015)

A reversed-phase HPLC-UV method was developed, optimized, and validated for the separation and quantitation of six target alkaloids from leaves of Nicotiana species (nicotine, nornicotine, anatabine, ...

Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats.

Drug Alcohol Depend. 153 , 330-4, (2015)

While nicotine is the primary addictive compound in tobacco, other tobacco constituents including minor alkaloids (e.g., nornicotine, anabasine) may also contribute to tobacco addiction by mimicking o...

Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: implications for nicotine product standards.

Exp. Clin. Psychopharmacol. 22(5) , 453-9, (2014)

Product standards that greatly reduce the content of nicotine within cigarettes may result in improved public health. The study presented here used an animal model to investigate whether individuals w...

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3-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine

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3-(3,4-Dihydro-2H-pyrrol-5-yl)pyridine

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MFCD00052019

3-(1-Pyrrolin-2-yl)pyridine

Myosmine

Pyridine,3-(3,4-dihydro-2H-pyrrol-5-yl)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Myosmine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Myosmine
Price: ￥2078.0/50mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Myosmine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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