4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid

Modify Date: 2025-08-21 17:46:52

4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid structure	Common Name	4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid
	CAS Number	3130-75-4	Molecular Weight	233.220
	Density	1.4±0.1 g/cm3	Boiling Point	442.1±28.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₁NO₄	Melting Point	119-121ºC
	MSDS	N/A	Flash Point	221.2±24.0 °C

Use of 4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid

4-(N-Phthalimidoyl)butanoic acid (compound FB) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-(N-Phthalimidoyl)butanoic acid can be combined with carrier proteins and used in antigen design[1].

Name	4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl) butanoic acid
Synonym	More Synonyms

Description	4-(N-Phthalimidoyl)butanoic acid (compound FB) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-(N-Phthalimidoyl)butanoic acid can be combined with carrier proteins and used in antigen design[1].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Mercader JV, et al. Development of monoclonal ELISAs for azinphos-methyl. 1. Hapten synthesis and antibody production. J Agric Food Chem. 1999 Mar;47(3):1276-84.

Density	1.4±0.1 g/cm3
Boiling Point	442.1±28.0 °C at 760 mmHg
Melting Point	119-121ºC
Molecular Formula	C₁₂H₁₁NO₄
Molecular Weight	233.220
Flash Point	221.2±24.0 °C
Exact Mass	233.068802
PSA	74.68000
LogP	1.58
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.605
InChIKey	HMKSXJBFBVGLJJ-UHFFFAOYSA-N
SMILES	O=C(O)CCCN1C(=O)c2ccccc2C1=O

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR3459000

CHEMICAL NAME :: 2-Isoindolinebutyric acid, 1,3-dioxo-

CAS REGISTRY NUMBER :: 3130-75-4

BEILSTEIN REFERENCE NO. :: 0208243

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H11-N-O4

MOLECULAR WEIGHT :: 233.24

WISWESSER LINE NOTATION :: T56 BVNVJ C3VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 327 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 27,805,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 28,680,1973

Hazard Codes	Xi: Irritant;
HS Code	2925190090

Precursor 9
CAS#:85-44-9 Phthalic anhydride CAS#:56-12-2 4-Aminobutanoic acid CAS#:627-00-9 4-Chlorobutyric acid CAS#:1074-82-4 Potassium phtha...
CAS#:22509-74-6 N-carbethoxypht... CAS#:340-90-9 N-phthaloyl-L-g... CAS#:88-99-3 Phthalic acid CAS#:2913-97-5 N-(2-Oxoethyl)p...
CAS#:16011-10-2 (Z)-4-phthalimi...
DownStream 10
CAS#:41306-64-3 2-(5-bromo-4-ox... CAS#:35197-64-9 2-BROMO-4-(1,3-... CAS#:10314-06-4 1-(2-Phthalimid... CAS#:3459-33-4 4-(1,3-dioxoiso...
CAS#:3598-60-5 4-(1,3-DIOXOISO... CAS#:3589-45-5 2H-Isoindole-2-... CAS#:56-12-2 4-Aminobutanoic acid CAS#:84461-00-7 1-diazonio-5-(1...
CAS#:94106-03-3 4-amino-2-bromo... CAS#:40557-20-8 3-Bromopyrrolid...

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Name: qHTS screening for TAG (triacylglycerol) accumulators in algae
Source: 11812
Target: N/A
External Id: FATTTLab-Algae-Lipid

Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262

Name: Small-molecule inhibitors of ST2 (IL1RL1)
Source: 20881
Target: interleukin-1 receptor-like 1 isoform [homo sapiens]
External Id: ST2_IL33_Inhibitors_Primary_Screening_77700

Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979

Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

Name: A screen for compounds that inhibit viral RNA polymerase binding and polymerization a...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Chain A, Poliovirus Polymerase With Gtp
External Id: HMS750

Name: Hypolipidemic activity (14th day serum triglyceride) at 20 mg/kg in CF1 male mice
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL731617

Name: Inhibitors of CDC25B-CDK2/CyclinA interaction
Source: Center for Chemical Genomics, University of Michigan
External Id: MScreen:TargetID_600

Name: Hypolipidemic activity (9th day serum cholesterol) at 20 mg/kg in CF1 male mice
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL731619

Name: Hypolipidemic activity (16th day serum cholesterol) at 20 mg/kg in CF1 male mice
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL731618

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MFCD00196079

4-(1,3-dioxoisoindol-2-yl)butanoic acid

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

4-Phthalimidobutyric Acid

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Chainpharm Limited
China
Product Name: 4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid
Price: ￥Inquiry/1g ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg
Purity: 97.0%
Delivery: 14 Day
Contact: Manufacturer CRO CDMO
Email: sales@chainpharm.com

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4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid

Use of 4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid

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MSDS

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