PhiKan 083

Modify Date: 2024-01-20 19:43:56

PhiKan 083 structure	Common Name	PhiKan 083
	CAS Number	880813-36-5	Molecular Weight	238.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PhiKan 083

PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3].

Name	1-(9-Ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride (1 :1)
Synonym	More Synonyms

Description	PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3].
Related Catalog	Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Cancer
Target	Kd: 167 μM (p53-Y220C)[1], 150 μM (p53Y220C, in Ln229 cells)[3]
In Vitro	PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR[1], shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells[3]. PhiKan083 slows down its thermal denaturation rate[2]. PhiKan 083 (125 μM) reduces the cell viability of engineered variants of Ln229 cells. PhiKan 083 (100 μM) in conbination with doxorubicin (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p535, p53Y220C, p53G245S, p53R282W)[3].
References	[1]. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. [2]. Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74. [3]. Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511.

Molecular Formula	C₁₆H₁₈N₂
Molecular Weight	238.33
PSA	16.96000
LogP	4.72670
Storage condition	2-8℃

PhiKan 083

DC Chemicals Limited
China
Product Name: PhiKan 083
Price: $550.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PhiKan-083 Hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

PhiKan 083 suppliers

Price: ￥1375/10 mM * 1 mL in DMSO

Reference only. check more PhiKan 083 price

PhiKan 083

Use of PhiKan 083

Names

PhiKan 083 Biological Activity

Chemical & Physical Properties

Synonyms