α-Conotoxin MI trifluoroacetate salt structure
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Common Name | α-Conotoxin MI trifluoroacetate salt | ||
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CAS Number | 88217-10-1 | Molecular Weight | 1493.72000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C58H88N22O17S4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of α-Conotoxin MI trifluoroacetate saltα-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2]. |
Name | GRCCHPACGKNYSC-amide, cyclic (3→8),(4→14)-bis(disulfide) |
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Synonym | More Synonyms |
Description | α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2]. |
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Related Catalog | |
Target |
mAChR[2]; α1β1γδ nAChR[1] |
In Vitro | α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits[2]. |
Molecular Formula | C58H88N22O17S4 |
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Molecular Weight | 1493.72000 |
Exact Mass | 1492.56000 |
PSA | 739.97000 |
alpha-conotoxin MI |
α-Conotoxin MI trifluoroacetate salt |