α-Conotoxin MI trifluoroacetate salt

Modify Date: 2024-01-19 16:41:42

α-Conotoxin MI trifluoroacetate salt Structure
α-Conotoxin MI trifluoroacetate salt structure
Common Name α-Conotoxin MI trifluoroacetate salt
CAS Number 88217-10-1 Molecular Weight 1493.72000
Density N/A Boiling Point N/A
Molecular Formula C58H88N22O17S4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-Conotoxin MI trifluoroacetate salt


α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].

 Names

Name GRCCHPACGKNYSC-amide, cyclic (3→8),(4→14)-bis(disulfide)
Synonym More Synonyms

 α-Conotoxin MI trifluoroacetate salt Biological Activity

Description α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].
Related Catalog
Target

mAChR[2]; α1β1γδ nAChR[1]

In Vitro α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits[2].

 Chemical & Physical Properties

Molecular Formula C58H88N22O17S4
Molecular Weight 1493.72000
Exact Mass 1492.56000
PSA 739.97000

 Synonyms

alpha-conotoxin MI
α-Conotoxin MI trifluoroacetate salt
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