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581-05-5

581-05-5 structure
581-05-5 structure
  • Name: α-MSH trifluoroacetate salt
  • Chemical Name: α-Melanocyte stimulating hormone
  • CAS Number: 581-05-5
  • Molecular Formula: C77H109N21O19S
  • Molecular Weight: 1664.884
  • Catalog: Biochemical Peptide
  • Create Date: 2018-09-10 09:36:54
  • Modify Date: 2025-09-11 21:59:19
  • α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
Name α-Melanocyte stimulating hormone
Synonyms N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
α-Melanocyte Stimulating Hormone
MFCD00133062
L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-
α-MSH
Description α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
Related Catalog
Target

Melanocortin 1 receptor[1] Adenylyl cyclase[1]

In Vitro α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2].
In Vivo α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2].
References

[1]. Jo H, et al. Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3374-3377.

[2]. Lu XY, et al. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci. 2003 Aug 27;23(21):7863-72.
Density 1.5±0.1 g/cm3
Molecular Formula C77H109N21O19S
Molecular Weight 1664.884
Exact Mass 1663.792969
PSA 668.28000
LogP -1.77
Index of Refraction 1.682
Storage condition 2-8°C
Water Solubility Soluble in water (~1 mg/ml).
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes N
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
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title: CAS No. 581-05-5 | Chemsrc address: https://m.chemsrc.com/en/baike/587323.html

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