α-MSH trifluoroacetate salt
α-MSH trifluoroacetate salt structure
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Common Name | α-MSH trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 581-05-5 | Molecular Weight | 1664.884 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C77H109N21O19S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of α-MSH trifluoroacetate saltα-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. |
| Name | α-Melanocyte stimulating hormone |
|---|---|
| Synonym | More Synonyms |
| Description | α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. |
|---|---|
| Related Catalog | |
| Target |
Melanocortin 1 receptor[1] Adenylyl cyclase[1] |
| In Vitro | α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2]. |
| In Vivo | α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C77H109N21O19S |
| Molecular Weight | 1664.884 |
| Exact Mass | 1663.792969 |
| PSA | 668.28000 |
| LogP | -1.77 |
| Index of Refraction | 1.682 |
| Storage condition | 2-8°C |
| Water Solubility | Soluble in water (~1 mg/ml). |
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Triterpene glycosides and other polar constituents of shea (Vitellaria paradoxa) kernels and their bioactivities.
Phytochemistry 108 , 157-70, (2014) The MeOH extract of defatted shea (Vitellaria paradoxa; Sapotaceae) kernels was investigated for its constituents, and fifteen oleanane-type triterpene acids and glycosides, two steroid glucosides, tw... |
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Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.
Endocrinology 156(4) , 1372-85, (2015) Proopiomelanocortin (POMC)-derived peptides like α-melanocyte-stimulating hormone (MSH) substantially improve hepatic insulin sensitivity and regulate energy expenditure. Melanocortinergic agents are ... |
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Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat.
PLoS ONE 7(12) , e53111, (2012) We have previously reported that chemical stimulation of the hypothalamic arcuate nucleus (ARCN) in the rat elicited increases as well as decreases in blood pressure (BP) and sympathetic nerve activit... |
| N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide |
| α-Melanocyte Stimulating Hormone |
| MFCD00133062 |
| L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl- |
| α-MSH |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: α-MSH trifluoroacetate salt
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Nanjing Peptide Biotech Ltd
- China
- Product Name: α-MSH
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Delivery: 7 Day
- Contact: jom
- Email: chenglong.fan@njpeptide.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: D-(-)-CITRAMALIC ACID
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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