HJC 0350
Modify Date: 2025-08-23 10:33:49
HJC 0350 structure
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Common Name | HJC 0350 | ||
|---|---|---|---|---|
| CAS Number | 885434-70-8 | Molecular Weight | 277.38200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H19NO2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of HJC 0350HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM. |
| Name | 2,4-dimethyl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole |
|---|---|
| Synonym | More Synonyms |
| Description | HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM. |
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| Related Catalog | |
| Target |
IC50: 0.3 µM (EPAC2)[1] |
| In Vitro | HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET[1]. |
| References |
| Molecular Formula | C15H19NO2S |
|---|---|
| Molecular Weight | 277.38200 |
| Exact Mass | 277.11400 |
| PSA | 47.45000 |
| LogP | 4.34790 |
| Storage condition | -20℃ |
| Hazard Codes | N |
|---|---|
| RIDADR | NONH for all modes of transport |
| HJC0350 |
| HJC-0350 |