Bafilomycin B1

Modify Date: 2024-01-06 11:56:47

Bafilomycin B1 structure	Common Name	Bafilomycin B1
	CAS Number	88899-56-3	Molecular Weight	815.986
	Density	1.2±0.1 g/cm3	Boiling Point	939.4±65.0 °C at 760 mmHg
	Molecular Formula	C₄₄H₆₅NO₁₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	521.9±34.3 °C
	Symbol	GHS06	Signal Word	Danger

Use of Bafilomycin B1

Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1].

Name	Bafilomycin B1
Synonym	More Synonyms

Description	Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7972-6.

Density	1.2±0.1 g/cm3
Boiling Point	939.4±65.0 °C at 760 mmHg
Molecular Formula	C₄₄H₆₅NO₁₃
Molecular Weight	815.986
Flash Point	521.9±34.3 °C
Exact Mass	815.445618
PSA	207.38000
LogP	3.06
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.563
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NG8841000

CHEMICAL NAME :: Hygrolidin, 37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclo penten-1-yl)amino)car bonyl)- 2-methoxy-24-methyl-

CAS REGISTRY NUMBER :: 88899-56-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C44-H65-N-O13

MOLECULAR WEIGHT :: 816.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1253,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H310 + H330
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	36/37/39-45
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	NG8841000

Precursor 0
DownStream 1
CAS#:65518-38-9 (E)-4-[(2-hydro...

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988)

Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast,...

Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E.

Biochim. Biophys. Acta 1126(1) , 41-8, (1992)

Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 mi...

The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells.

Cell Biol. Toxicol. 22(3) , 169-81, (2006)

Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the prot...

(5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose

BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO-MYCES SPECIES

bafilomycin b1from streptomyces sp.

α-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-3 -O-[(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-buten-1-yl]-4-methyl-5-C-(1-methylethyl)-, (5R)-

ino)carbonyl)-2-methoxy-24-methyl

BafilomycinB1fromStreptomycesgriseus

MFCD00214150