WDR5 0103

Modify Date: 2024-01-09 18:44:56

WDR5 0103 Structure
WDR5 0103 structure
 Common Name WDR5 0103
CAS Number 890190-22-4 Molecular Weight 383.441
Density 1.2±0.1 g/cm3 Boiling Point 495.2±45.0 °C at 760 mmHg
Molecular Formula C21H25N3O4 Melting Point N/A
MSDS Chinese Flash Point 253.3±28.7 °C
Symbol GHS09
GHS09		 Signal Word Warning

 Use of WDR5 0103


WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.IC50 value: 450 nM (Kd)Target: WDR5in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.

 Names

Name Methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benz oate
Synonym More Synonyms

 WDR5 0103 Biological Activity

Description WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.IC50 value: 450 nM (Kd)Target: WDR5in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.
Related Catalog
References

[1]. Senisterra G, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-159.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 495.2±45.0 °C at 760 mmHg
Molecular Formula C21H25N3O4
Molecular Weight 383.441
Flash Point 253.3±28.7 °C
Exact Mass 383.184509
PSA 74.60000
LogP 2.63
Appearance of Characters light yellow solid
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.603
Storage condition -20℃

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
RIDADR UN 3077 9 / PGIII

 Synonyms

Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester
Methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methylpiperazin-1-yl)benzoate
Methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoate
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
WDR5-0103
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Chemsrc provides WDR5 0103(CAS#:890190-22-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of WDR5 0103 are included as well.>> amp version: WDR5 0103

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