Delta-Gluconolactone

Modify Date: 2026-06-30 10:56:24

Delta-Gluconolactone structure	Common Name	Delta-Gluconolactone
	CAS Number	90-80-2	Molecular Weight	178.140
	Density	0.6	Boiling Point	230.35°C
	Molecular Formula	C₆H₁₀O₆	Melting Point	151-155 ºC
	MSDS	Chinese USA	Flash Point	192.3±20.3 °C

Use of Delta-Gluconolactone

D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	D-glucono-1,5-lactone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
Related Catalog	Natural Products >> Saccharides and Glycosides Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	D-(+)-Glucono-1,5-lactone is a lactone (cyclic ester) of D-gluconic acid. D-(+)-Glucono-1,5-lactone is commonly found in honey, fruit juices, personal lubricants, and wine. D-(+)-Glucono-1,5-lactone is neutral, but hydrolyses in water to gluconic acid which is acidic, adding a tangy taste to foods, though it has roughly a third of the sourness of citric acid. It is metabolized to glucose; one gram of D-(+)-Glucono-1,5-lactone yields roughly the same amount of metabolicenergy as one gram of sugar. Upon addition to water, GDL is partially hydrolysed to gluconic acid, with the balance between the lactone form and the acid form established as a chemical equilibrium. The rate of hydrolysis of D-(+)-Glucono-1,5-lactone is increased by heat and high pH[1].
References	[1]. Xu Y, et al. Aggregation and structural changes of silver carp actomyosin as affected by mild acidification with D-gluconic acid δ-lactone. Food Chem. 2012 Sep 15;134(2):1005-10.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.6
Boiling Point	230.35°C
Melting Point	151-155 ºC
Molecular Formula	C₆H₁₀O₆
Molecular Weight	178.140
Flash Point	192.3±20.3 °C
Exact Mass	178.047745
PSA	107.22000
LogP	-2.38
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.608
InChIKey	PHOQVHQSTUBQQK-SQOUGZDYSA-N
SMILES	O=C1OC(CO)C(O)C(O)C1O
Water Solubility	500 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Delta-Gluconolactone MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5184000

CHEMICAL NAME :: Gluconic acid, delta-lactone, D-

CAS REGISTRY NUMBER :: 90-80-2

LAST UPDATED :: 199803

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H10-O6

MOLECULAR WEIGHT :: 178.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 5 mmol/L

REFERENCE :: AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974- Volume(issue)/page/year: 109,157,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80419 No. of Facilities: 3748 (estimated) No. of Industries: 25 No. of Occupations: 33 No. of Employees: 20328 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80419 No. of Facilities: 3645 (estimated) No. of Industries: 12 No. of Occupations: 28 No. of Employees: 184229 (estimated) No. of Female Employees: 157249 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R21
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LZ5184000
HS Code	2932999099

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:2280-44-6 D-glucopyranose CAS#:50-99-7 D-(+)-Glucose CAS#:526-95-4 D-Gluconic acid CAS#:492-61-5 β-D-Glucopyranose
CAS#:7440-06-4 platinum CAS#:7440-05-3 Palladium CAS#:492-62-6 dextrose CAS#:110-71-4 1,2-dimethoxyethane
CAS#:74421-63-9 ethyl D-gluconate CAS#:71-36-3 Butanol
DownStream 10
CAS#:526-95-4 D-Gluconic acid CAS#:50-70-4 Sorbitol CAS#:18375-65-0 N-hexadecyl-D-g... CAS#:18375-57-0 N-butyl-D-gluco...
CAS#:18375-64-9 N-tetradecyl-D-... CAS#:18375-61-6 N-octyl-D-gluco... CAS#:27934-92-5 methyl 2-(hydro... CAS#:24758-69-8 D-Gluconamide,N...
CAS#:695-06-7 γ-Caprolactone CAS#:13149-68-3 D-gluconic acid...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Altern. Lab. Anim. 43 , 101-27, (2015)

The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers.

Biomacromolecules 16 , 3562-73, (2015)

In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inflammatory drug naproxen and C-terminal dehydroamino acids, dehydrophenylalanine (ΔPhe), dehydroaminob...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

D-Gluconolactone

EINECS 202-016-5

δ-Gluconolactone

(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one

D-Gluconic acid-1,5-lactone

D-Glucono-1,5-lactone

D-Glucono-d-lactone

gluconolactone

D-Gluconic acid 1,5-lactone

d-gluconic acid d-lactone

Delta-Gluconolactone

Gluconic acid lactone

δ-Gluconic acid d-lactone

δ-Gluconic acid δ-lactone

MFCD00006647

Glucono δ-lactone

D-Gluconic acid lactone

D-Gluconic acid, δ-lactone

D-(+)-Glucono-1,5-lactone

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of D-glucono-1,5-lactone?

A: CAS number of D-glucono-1,5-lactone is 90-80-2.

Q: What is the safety information for D-glucono-1,5-lactone?

A: Safety information for D-glucono-1,5-lactone: S24/25.

Q: What are the upstream materials of D-glucono-1,5-lactone?

A: Related upstream materials(CAS) of D-glucono-1,5-lactone: 2280-44-6;50-99-7;526-95-4;492-61-5;7440-06-4;7440-05-3;492-62-6;110-71-4;74421-63-9;71-36-3.

Q: What is the molecular formula of D-glucono-1,5-lactone?

A: Molecular formula of D-glucono-1,5-lactone is C6H10O6.

Q: What is the polar surface area (PSA) of D-glucono-1,5-lactone?

A: Polar surface area (PSA) of D-glucono-1,5-lactone is 107.22000.

Q: What is the melting point of D-glucono-1,5-lactone?

A: Melting point of D-glucono-1,5-lactone is 151-155 ºC.

Q: What is the LogP of D-glucono-1,5-lactone?

A: LogP of D-glucono-1,5-lactone is -2.38.

Q: How is the water solubility of D-glucono-1,5-lactone?

A: Water solubility of D-glucono-1,5-lactone: 500 g/L (20 ºC).

Q: What is the SMILES notation of D-glucono-1,5-lactone?

A: SMILES notation of D-glucono-1,5-lactone is O=C1OC(CO)C(O)C(O)C1O.

Q: What is the InChIKey of D-glucono-1,5-lactone?

A: InChIKey of D-glucono-1,5-lactone is PHOQVHQSTUBQQK-SQOUGZDYSA-N.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Delta-Gluconolactone
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: delta-Gluconolactone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: delta-Gluconolactone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Delta-Gluconolactone
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Delta-Gluconolactone suppliers

Price: ￥500/5 g

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Delta-Gluconolactone

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