PIK-293

Modify Date: 2024-01-12 11:21:36

PIK-293 Structure
PIK-293 structure
Common Name PIK-293
CAS Number 900185-01-5 Molecular Weight 397.433
Density 1.4±0.1 g/cm3 Boiling Point 657.3±65.0 °C at 760 mmHg
Molecular Formula C22H19N7O Melting Point N/A
MSDS N/A Flash Point 351.3±34.3 °C

 Use of PIK-293


PIK-293, an analog of IC87114, is a PI3K inhibitor, with IC50 values of 0.24 μM, 10 μM, 25 μM and 100 μM for p110δ, p110β, p110γ and p110α, respectively[1].

 Names

Name 2-[(4-aminopyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one
Synonym More Synonyms

 PIK-293 Biological Activity

Description PIK-293, an analog of IC87114, is a PI3K inhibitor, with IC50 values of 0.24 μM, 10 μM, 25 μM and 100 μM for p110δ, p110β, p110γ and p110α, respectively[1].
Related Catalog
Target

PI3Kδ:0.24 μM (IC50)

PI3Kβ:10 μM (IC50)

PI3Kγ:25 μM (IC50)

PI3Kα:100 μM (IC50)

References

[1]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 657.3±65.0 °C at 760 mmHg
Molecular Formula C22H19N7O
Molecular Weight 397.433
Flash Point 351.3±34.3 °C
Exact Mass 397.165100
PSA 104.51000
LogP 2.18
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.759
Storage condition -20℃

 Synonyms

PIK-293-Supplied by Selleck Chemicals
S2207_Selleck
cc-612
2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
X7412
2-[(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
4(3H)-Quinazolinone, 2-[(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)-
PIK-293
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