AMG1
Modify Date: 2024-01-11 07:09:20
AMG1 structure
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Common Name | AMG1 | ||
|---|---|---|---|---|
| CAS Number | 903591-53-7 | Molecular Weight | 413.729 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 411.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H9ClF5N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 202.4±28.7 °C | |
Use of AMG1A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases. |
| Name | N-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl}-2,6-difluorobenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases. |
|---|---|
| References | References 1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85. View Related Products by Target Calcium Channel |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 411.1±45.0 °C at 760 mmHg |
| Molecular Formula | C18H9ClF5N3O |
| Molecular Weight | 413.729 |
| Flash Point | 202.4±28.7 °C |
| Exact Mass | 413.035431 |
| LogP | 4.00 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.582 |
| MFCD27924112 |
| Benzamide, N-[5-[2-chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl]-2,6-difluoro- |
| N-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl}-2,6-difluorobenzamide |